yeah, the constant nitpicking about things she can't help is annoying. people are desperate for milk so they'll try to make a topic out of everything. for example, that anon who was saying how gross her arm looks because it has stretch marks and loose skin. what's she supposed to do about that? shes a shitty person but i gaurentee none of the anons on this thread are perfect or even attractive enough to be such nitpickers
Well, I see it as nitpicking because it's not funny, boring and over talked about. We all know she has saggy tits, it doesn't need to be pointed out every time a new pic is posted. and I've always thought and said she hated herself before the tit thing, it's not that people are suddenly jumping to this conclusion now, it just started a discussion about it.
Polycystic ovary syndrome is the most common endocrinopathy among reproductive-aged women in the United States, affecting approximately 7% of female patients. Although the pathophysiology of the syndrome is complex and there is no single defect from which it is known to result, it is hypothesized that insulin resistance is a key factor. Metabolic syndrome is twice as common in patients with polycystic ovary syndrome compared with the general population, and patients with polycystic ovary syndrome are four times more likely than the general population to develop type 2 diabetes mellitus. Patient presentation is variable, ranging from asymptomatic to having multiple gynecologic, dermatologic, or metabolic manifestations. Guidelines from the Endocrine Society recommend using the Rotterdam criteria for diagnosis, which mandate the presence of two of the following three findings—hyperandrogenism, ovulatory dysfunction, and polycystic ovaries—plus the exclusion of other diagnoses that could result in hyperandrogenism or ovulatory dysfunction. It is reasonable to delay evaluation for polycystic ovary syndrome in adolescent patients until two years after menarche. For this age group, it is also recommended that all three Rotterdam criteria be met before the diagnosis is made. Patients who have marked virilization or rapid onset of symptoms require immediate evaluation for a potential androgen-secreting tumor. Treatment of polycystic ovary syndrome is individualized based on the patient's presentation and desire for pregnancy. For patients who are overweight, weight loss is recommended. Clomiphene and letrozole are first-line medications for infertility. Metformin is the first-line medication for metabolic manifestations, such as hyperglycemia. Hormonal contraceptives are first-line therapy for irregular menses and dermatologic manifestations.
The effectiveness of aromatase inhibitors in the treatment of PCOS remains controversial. A meta-analysis investigated 78 studies on the use of these medications in the infertility treatment of women with PCOS. Of these studies, 13 RCTs met the inclusion criteria. Six studies compared the use of letrozole versus CC and found that letrozole presented with a higher ovulation rate/patient (OR 2.90; 95% CI: 1.72- 4.88; p<0.0001); however, no significant differences in the rate of ovulation per cycle or better pregnancy, live birth, multiple pregnancy or miscarriages rates were noted. Letrozole also did not obtain better results regarding clinical pregnancy or live birth rates compared with placebo or CC + metformin in women with CC-resistant PCOS. The results of the comparison of the effects of letrozole and anastrozole on ovulation and pregnancy rates in women with CC-resistant PCOS are controversial 41.
The diagnostic workup should begin with a thorough history and physical examination. Clinicians should focus on the patient's menstrual history, any fluctuations in the patient's weight and their impact on PCOS symptoms, and cutaneous findings (e.g., terminal hair, acne, alopecia, acanthosis nigricans, skin tags).19 Patients should also be asked about factors related to common comorbidities of PCOS.
Clomid Active ingredient: clomiphene $0.44 for pill Clomid is a fertility drug, used to stimulate FSH and LH production and hereby the ovaries to produce eggs in ovarian disorders. Metformin Active ingredient: metformin $0.26 for pill Metformin is a biguanide anti-diabetic that works by decreasing the amount of sugar that the liver produces and the intestines absorb.
The prescription cream eflornithine HCl can slow the growth of new hair when applied as directed on the face and other areas – but it won’t remove existing hair. 20,21 Your doctor may also prescribe a medication called an anti-androgen. In the United States, a medication called spironolactone is used to slow new hair growth. In other countries, cyproterone acetate is widely used but it is not available in the United States.
34. Griesinger G, Schultz L, Bauer T, Broessner A, Frambach T, Kissler S. Ovarian hyperstimulation syndrome prevention by gonadotropin-releasing hormone agonist triggering of final oocyte maturation in a gonadotropin-releasing hormone antagonist protocol in combination with a "freeze-all" strategy: a prospective multicentric study. Fertil Steril. 2011;95(6):2029–33. http://dx.doi.org/10.1016/j.fertnstert.2011.01.163 [PubMed]
In contrast, another recent meta-analysis reviewed 26 studies that evaluated the use of letrozole in women with PCOS. The use of letrozole in cycles for timed intercourse was associated with higher live birth (nine studies; OR 1.63; 95% CI: 1.31 to 2.03; n=1783; I2=3%) and clinical pregnancy rates (fourteen studies; OR 1.32; 95% CI: 1.09 to 1.60; n=2066; I2=25%) compared with CC treatment; however, this evidence was poor. Studies comparing the use of letrozole versus ovarian drilling revealed no differences in live birth, clinical pregnancy or OHSS rates. The administration of letrozole for 5 or 10 days at a dose of 5 or 7.5 mg/day displayed similar clinical pregnancy rates 42. A recent study found that the use of letrozole was associated with higher live birth rates and ovulation among 750 infertile women with polycystic ovary syndrome compared with clomiphene 43.
Ano nga ba ang PCOS? Ito ay isang hormonal disorder kung saan nagkakaroon ang babae ng mga maliliit na cyst sa kanyang obaryo. Naglalaman ang mga cyst na ito ng mga immature egg cells na hindi kayang mag-trigger ng proseso ng obulasyon. Ibig sabihin, bababa ang lebel ng female hormones tulad ng estrogen at progesterone, at tataas ang lebel ng male hormones katulad ng androgen. Ang imbalance na ito ay magdadala ng iba’t ibang sintomas at epekto sa katawan.
Metformin has been the mainstay of treatment for IR and IGT in PCOS women over the past decade. Metformin is a biguanide that acts principally on the liver to inhibit hepatic gluconeogenesis. It also inhibits acetyl-CoA carboxylase activity and suppresses fatty acid production. Metformin acts on skeletal muscle to inhibit lipid production and acts peripherally on adipose tissue to stimulate glucose transport and uptake. Metformin reduces insulin levels and promotes improved insulin receptor activity. Metformin may also have direct and indirect effects on the ovary with respect to insulin action and steroidogenic enzymatic activity. In the endothelium, metformin seems to improve nitric oxide vasodilatory effects. Many other mechanisms of action have been studied in both animal and human models but consistent effects are not always demonstrated with local tissue concentrations that result from therapeutic doses.
Es posible que el médico pida análisis de sangre de niveles hormonales, colesterol o glucosa (azúcar) en la sangre. A veces, los médicos hacen un examen pélvico o piden exámenes de ultrasonido (con imágenes) de los ovarios y el útero. Este tipo de prueba puede mostrar si usted tiene quistes ováricos, que son burbujas llenas de líquido dentro o fuera de los ovarios. Su médico se asegurará de que no existan otras causas de períodos irregulares o alteraciones en el nivel hormonal.
I was diagnosed with pcos while using implanon birth control in November 2012. I was told it was che...mical, it was symptom and blood diagnosed not with cysts on my ovaries. My ob/gyn told me that implanon can cause pcos and many other terrible medical conditions. I had it removed in January 2013 and have been trying to get pregnant since, after being told I needed a hysterectomy. (I was 24). In the past year I have gotten pregnant twice, both ended with miscarriage. In January this year, I had my blood tested again and I am almost completely normal. I'll always have pcos, it's life long, but the fact that after a year of getting the implanon removed I was able to get my blood back to normal. My endocrinologist called it miraculous!
That makes a lot of sense. It's kind of a shame, though; although he does keep a roof over her head, which is much more than she could hope for (though she'll probably end up homeless at some point anyway), imo she would have kept her tumblr following and suckers who'd donate much longer had she dated somebody who matched her aesthetic and who she could take ~cool~ photo ops with rather than a dirty older man who serves to illustrate how miserable and unglamorous the lifestyle really is. Her relationship with Lurch has caused her to become almost a PSA about what junkie life is like beneath all the staging so many of them do on social media.
A total of 33 studies were included in this review. Eighteen pre-clinical studies reported mechanisms of effect and fifteen clinical studies corroborated pre-clinical findings, including eight randomised controlled trials, and 762 women with menstrual irregularities, hyperandrogenism and/or PCOS. Interventions included herbal extracts of Vitex agnus-castus, Cimicifuga racemosa, Tribulus terrestris, Glycyrrhiza spp., Paeonia lactiflora and Cinnamomum cassia. Endocrine outcomes included reduced luteinising hormone (LH), prolactin, fasting insulin and testosterone. There was evidence for the regulation of ovulation, improved metabolic hormone profile and improved fertility outcomes in PCOS. There was evidence for an equivalent effect of two herbal medicines and the pharmaceutical agents bromocriptine (and Vitex agnus-castus) and clomiphene citrate (and Cimicifuga racemosa). There was less robust evidence for the complementary combination of spirinolactone and Glycyrrhiza spp. for hyperandrogenism.
i wonder if luna's dad knows about how much she complains about him. all he would have to do is google her name to see how much she hates him. if i were her dad and i saw the shit she says about me, i'd kick her to the curb. poor dude is letting her have what she wants, when she wants it, and she STILL talks about him like he's a monster. maybe he's a piece of shit but damn, at least he's trying. what an ungrateful brat
Hai ask ko LNG po my folycystic ovary po ako nag pa check up ako sa ob onang painom nya sa akin is provera sa ika 11days ako niregla patak patak lang at ang sakit sa puson ko ..di na rin ako pwd uminom ng provers kc hanggng 10days LNG saw dapat ..pakiramdam ko Hindi makalabas kaya masakit ..my pwd ba along gawin opang lumakas pa ng kunti ..2yrs npo kc akong Daley ngayun LNG ako niregla ulit 5/11/2016 namamanhd din po balakang ko salamt po
The American College of Obstetricians and Gynecologists (ACOG) and the Society of Obstetricians and Gynaecologists of Canada (SOGC) indicate that lifestyle modifications such as weight loss and increased exercise in conjunction with a change in diet consistently reduce the risk of diabetes. This approach has been found to be comparable to or better than treatment with medication and should therefore be considered first-line treatment in managing women with polycystic ovarian syndrome (PCOS). [2, 3] These modifications have been effective in restoring ovulatory cycles and achieving pregnancy in obese women with PCOS. Weight loss in obese women with PCOS also improves hyperandrogenic features.
One study indicates that caloric intake timing can have a big impact on glucose, insulin and testosterone levels. Lowering insulin could potentially help with infertility issues. Women with PCOS who ate the majority of their daily calories at breakfast for 12 weeks significantly improved their insulin and glucose levels as well as decreased their testosterone levels by 50 percent, compared to women who consumed their largest meals at dinnertime. The effective diet consisted of a 980-calorie breakfast, a 640-calorie lunch, and a 190-calorie dinner.
Gud pm doc. Meron akung isang anak . Nung dalaga ako regular naman ang regla ko. Peru cmula nung nagka anak ako 3 to 4 months na aqng nireregla 22yrs old napu ako ngaun nung pnanganak ko ang bb ko 18yrs old palang ako. Mahgit 4years ng abnormal ang mens. Ko. At ngaun 2015 lang nalaman ko na meron dn pala akung non toxic goiter. Makakasama ba e2 sa akin. May posibilidad dn bang d na aq magka anak. At may posibilidad dn ba na magka cancer ako?
A diet patterned after the type 2 diabetes diet has been recommended for PCOS patients.  This diet emphasizes increased fiber; decreased refined carbohydrates, trans fats, and saturated fats; and increased omega-3 and omega-9 fatty acids. However, in some obese patients with PCOS, weight loss has improved menstrual regularity.  Omega-3 fatty acid supplementation has been shown to reduce liver fat content and other cardiovascular risk factors in women with PCOS, including those with hepatic steatosis, although these effects have not yet been proven to translate into a reduction in cardiometabolic events. 
Complementary medicine (CM) use by women has increased during the past ten years [7–11] with rates of use ranging between 26% and 91% [8, 9]. One of the popular types of CM is herbal medicine [11, 12]. Herbal medicines are known to contain pharmacologically active constituents with physiological effects on female endocrinology and have been positively associated with reduced incidences of breast cancer, osteoporosis and cardiovascular disease [13–18].
Androgens. All females make androgens (also referred to as “male hormones”), but there are often higher levels of androgens in women with PCOS. The excess androgens are produced mostly by the ovaries, but the adrenal glands can also be involved. Excess androgens are responsible for many PCOS symptoms including acne, unwanted hair, thinning hair, and irregular periods.
Hola, actualmente estoy tomando diane diario por que son las únicas anticonceptivas que me funcionan, no puedo dejarlas porque si no padezco de acne severo e hirsutismo. Podría combinar ambas cosas? Lo que me gustaría es poder dejarme las pastillas algunos períodos, o si por ejemplo quisiera ser madre, poder dejar los métodos anticonceptivos y no tener que pasarlo mal por esos problemas, se conseguiría con estas cápsulas a largo plazo?
Hirsutism is treated with a combination of approaches, including oral contraceptives with or without an antiandrogen, such as spironolactone, to lower levels or block actions of androgen on hair follicles. Oral contraceptives are often combined with antiandrogens to improve their clinical effect and to prevent pregnancy, since accidental exposure of the male fetus to antiantrogens can harm fetal development. A topical cream (eflornithine hydrochloride) also can be applied to treat facial hirsutism.
Si bien no se recomienda como primer tratamiento, existe una operación para el tratamiento de PCOS, llamada incisión ovárica. Se realiza un pequeño corte encima o debajo del ombligo y se inserta un pequeño instrumento llamado laparoscopio que sirve como telescopio en el abdomen. Durante la laparoscopía, el médico puede hacer punciones en el ovario con una aguja delgada que tiene corriente eléctrica para destruir una pequeña porción del ovario. La cirugía puede mejorar los niveles hormonales y la ovulación, aunque es posible que la mejoría dure solo unos meses.
Dandelion Root (Taraxacum officinale): This herb is an effective liver detoxifier and bile flow stimulant. It is used to cleanse the liver and get rid of any build-up of hormones. This clean up can stimulate the production of SHGB which also means free testosterone in the blood is decreased.7 Dandelion root is used for PCOS treatment because menstrual irregularities are often affected by the liver being backed up with excessive hormones.
Paeonia lactiflora in combination with Cinnamomum cassia Aqueous extract Unkei-to Paeonia lactiflora and Cinnamomum cassia combination was investigated for steroid hormonal effects on cultured human granulosa cells (obtained from women undergoing IVF). Cells were incubated with different doses for 48 hours  One clinical trial investigated the effects of Paeonia lactiflora and Cinnamomum cassia combination (Unkei-to) . This single arm study included amenorrheic women aged 17–29 years (n = 157) with a sub group of women with hyper-functioning oligo/amenorrhoea (n = 42). Ovulation occurred in 61.3% of primary amenorrheic women and in 27.3% of secondary amenorrheic women following two months of treatment . 1. Increased granulosa production of oestradiol .
Jump up ^ Legro, RS; Arslanian, SA; Ehrmann, DA; Hoeger, KM; Murad, MH; Pasquali, R; Welt, CK; Endocrine, Society (December 2013). "Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline". The Journal of Clinical Endocrinology and Metabolism. 98 (12): 4565–92. doi:10.1210/jc.2013-2350. PMC 5399492. PMID 24151290.
I actually felt really sad for her on a tumblr post once and gave her a spare fiver. the old dude seems to be the light of her life but hes always oding and shes always alone shooting up in public parks. the lack of hygiene seems to be like an "i dont feel human enough to be clean" thing. She's just so saddening I can't bring myself to laugh at all.
As many as 70% of PCOS women are insulin resistant and 10% have DM[20-22]. In PCOS women with normal glucose metabolism initially, the rate of conversion to abnormal glucose metabolism can be 25% over just three years. More alarming, insulin abnormalities are highly prevalent in adolescents with PCOS. Almost 20% of young Thai women with PCOS actually have DM. Overall, normal glucose levels on an OGTT do not predict IR and IR, despite normal glucose levels, is correlated with CRP, dyslipidemia and other CAD risk factors. Therefore, glucose levels alone lack the sensitivity to predict metabolic risk in PCOS patients. Precursor states of insulin abnormalities likely predict long term CAD risk well before glucose abnormalities. IR can be just as severe in diabetics and non-diabetics, stressing the seriousness of this metabolic impairment as a precursor and not a separate disease. Animal models have shown that IR alone damages myocardial cells, providing direct evidence of end organ disease. Human data link HOMA-IR to left ventricular dysfunction. Abnormal glucose metabolism short of IGT and DM still deserves attention, identification and treatment.