Gerhard I, Patek A, et al. [61] Randomised, double blind, placebo controlled trial. Ninety-six women with fertility disorders and confirmed infertility (2 years). Vitex agnus-castus 32.4 mg/d in the commercial preparation Mastodynon® liquid extract produced by Bionorica, Germany. Spontaneous menstruation, luteal phase length, serum hormone concentrations and pregnancy rates. Non-significant improvement in clinical parameters in 57.6% of women in treatment group versus 36.0% in placebo group, P = 0.069. Numbers too small for statistical significance in clinical outcomes.
Hi doc..may katanungan lang po sana ako.last year na diagnosed po na may PCOS ako,pro bago po madiagnosed un,3 months po ako dinudugo(ireg po ang period ko simula ng nag trabaho ako sa call center) kaya kala ko ok lng po un dahil sanay naman po ako na ireg kaya pinabayaan ko po ung 3 months na pag dudugo.naalarma lang po ako at nagpatingin sa ob dahil ung pang 3rd moth ng pag durugo,sjmobra na po ang lakas na pakiramdam ko po ay mauubusan ako ng dugo sa lakas at geabe po ang buo buo.dun po mag decide ako magpatingin agad ako pina transvaginal ng doctor,dun po lumabas na my pcos ako,at bukod po doon,sobrang kapal na po mg lining ng matres ko at nsa result din po nakalagay na rinerefer na po ako sa endocrinologist.pero ang ginawa po ng ob ko is pinainom ako ng provera at ipinaliwanag ang pcos at ung tungkol sa kapal ng lining ng matresko.nabahala po ako dahil sabi po sa akin,kelngan daw po ako raspahin dahil sa kapal nito.pro neg refuse din po ung ob ko gwn ung procedure na un dhl daw po wla pa po akong amak at asawa.kya,provera at after ng provera,althea pills lng po ang iniinom ko.ang tanong ko lng po doc,posible po ba na normal na ang matres ko dahil 1 year mhgit ndn po mula ng ngng ok ang period ko dahil sa pills?kung hindi po,ano po ba ang maipapayo nyo na gawin ko doc?nag babasa basa po kc ako,high risk dw po sa endometrial cancer ang gmitong case.by d way po doc,26 years old po ako.salamat po at sna masagot nyo po ako.Godbless

Skin Conditions: Very frustrating for many women with this disorder, skin conditions are difficult to hide and can on occasion be painful. From mild to severe acne to the development of skin tags, skin conditions caused by Polycystic Ovarian Syndrome (PCOS) can be both a nuisance and an embarrassment. Additionally, women with PCOS can experience acanthosis nigricans, which is the development of dark, thick, almost velvet-like skin in several places on the body.2


For assisted reproduction cycles, metformin use prior to or during ovarian stimulation with gonadotropins in IVF/ICSI cycles is also not associated with better clinical pregnancy or live birth rates; however, metformin may reduce the risk of OHSS 38,39 and miscarriage and improve the implantation rate because metformin may act directly on the endometrium 39 and promote better reproductive outcomes (data not confirmed) in women with PCOS 40. However, as previously mentioned, the use of a GnRH antagonist combined with ovarian stimulation with gonadotropins in women with PCOS and the induction of final ovarian maturation with a GnRH agonist with subsequent embryo cryopreservation are more effective strategies to prevent OHSS regardless of metformin use 33. Thus, the routine use of metformin in cycles of ovarian stimulation for IVF in women with PCOS is not recommended except in the presence of a disorder in glucose metabolism 9.


Metformin has been the mainstay of treatment for IR and IGT in PCOS women over the past decade. Metformin is a biguanide that acts principally on the liver to inhibit hepatic gluconeogenesis. It also inhibits acetyl-CoA carboxylase activity and suppresses fatty acid production. Metformin acts on skeletal muscle to inhibit lipid production and acts peripherally on adipose tissue to stimulate glucose transport and uptake. Metformin reduces insulin levels and promotes improved insulin receptor activity[64]. Metformin may also have direct and indirect effects on the ovary with respect to insulin action and steroidogenic enzymatic activity. In the endothelium, metformin seems to improve nitric oxide vasodilatory effects. Many other mechanisms of action have been studied in both animal and human models but consistent effects are not always demonstrated with local tissue concentrations that result from therapeutic doses[65].

Reproductive dysfunction in PCOS women may also be a manifestation of IR. Menstrual cycle irregularity has been correlated with HOMA-IR[37]. Molecular defects in insulin action may be responsible for reproductive difficulties in PCOS women. Although endometrial tissue appears morphologically similar in PCOS to controls and may have similar insulin receptor prevalence, insulin receptor action at the local endometrial level is impaired and may be reflected in lower pregnancy implantation rates[38]. HOMA-IR has been correlated with follicle count in PCOS during in vitro fertilization[39]. Follicular insulin levels correlate with pregnancy outcome after IVF[40]. These are areas of unresolved understanding with regard to PCOS. Proposed mechanisms for insulin reproductive abnormalities include abnormalities of ovarian steroidogenesis, excessive LH secretion and abnormalities in glucose uptake[41]. PCOS women have been found to have post-receptor insulin abnormalities as well as reduced peripheral insulin receptor binding[42].
About Blog Verity is the UK charity for women with PCOS and supports thousands of women living with polycystic ovary syndrome. Verity's mission is to improve the lives of women with polycystic ovary syndrome (PCOS) which we aim to do by: - Supporting and empowering women with PCOS - Improving the quality of, access to, and choice of treatments available.

This is a great place for any event: there is a restaurant area for lunches and dinners, small tables for romantic evenings, a lounge area equipped with comfortable sofas and low tables, as well as a huge bar and a dance floor. AQUA LUNA’s summer terrace offers a splendid view onto the yacht club, the spires and roofs of the medieval Old Town, Vanšu Bridge, and modern business buildings – it is the ideal place to enjoy sunshine during the day, sunsets in evenings, and moonlight. In colder weather, AQUA LUNA warms hearts with its cosy atmosphere during long dinners by the fireplace and cheerful weekend parties.
From a practical standpoint, the use of aromatase inhibitors may be an option before IVF/ICSI after counseling and the consent of the couple in specific cases of women with CC-resistant PCOS without other infertility factors and for whom the high-complexity treatment is cost-prohibitive 41. The recommended dose of letrozole is 5 to 10 mg/day for 5 to 10 days.
Pre-clinical and clinical evidence was found for Vitex agnus-castus for lowered prolactin, improved menstrual regularity and treatment of infertility. Vitex agnus-castus contains a variety of compounds which bind to dopamine type 2 (DA-2) receptors in the brain; reduce cyclic adenosine mono phosphate (cAMP) and lowered prolactin secretion (Table 1). This was demonstrated in studies using recombinant DA-2 receptor proteins, and basal and stimulated rat pituitary cell cultures [38–41]. Prolactin lowering effects were found in normal and ovariectomised rats [49]. Additional agonistic opiate effects were observed in studies using human opiate receptors cell cultures [70].
Jump up ^ Wu, XK; Stener-Victorin, E; Kuang, HY; Ma, HL; Gao, JS; Xie, LZ; Hou, LH; Hu, ZX; Shao, XG; Ge, J; Zhang, JF; Xue, HY; Xu, XF; Liang, RN; Ma, HX; Yang, HW; Li, WL; Huang, DM; Sun, Y; Hao, CF; Du, SM; Yang, ZW; Wang, X; Yan, Y; Chen, XH; Fu, P; Ding, CF; Gao, YQ; Zhou, ZM; Wang, CC; Wu, TX; Liu, JP; Ng, EHY; Legro, RS; Zhang, H; PCOSAct Study, Group. (27 June 2017). "Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial". JAMA. 317 (24): 2502–2514. doi:10.1001/jama.2017.7217. PMC 5815063. PMID 28655015.
Habang remedyo sa bahay ay maaaring maging isang mahusay na pagpipilian para sa paggamot ng PCOS, naghahanap ng medikal na tulong ay din napakahalaga sa karamihan ng mga oras. Makipag-usap sa iyong doktor tungkol sa iyong mga plano upang bigyan ng bahay remedyong subukan mo upang ang mga pinakamahusay na posibleng mga kumbinasyon ng paggamot ay maaaring devised para sa iyo. Gayundin, PCOS ay madalas na nauugnay sa isang hindi malusog lifestyle at diyeta. Para sa ito, kami ay compiled ng isang listahan ng mga maingat mga panukala na maaari mong sundin upang labanan ang kundisyong ito.
Jump up ^ Legro, Richard S.; Arslanian, Silva A.; Ehrmann, David A.; Hoeger, Kathleen M.; Murad, M. Hassan; Pasquali, Renato; Welt, Corrine K.; Endocrine Society (December 2013). "Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline". The Journal of Clinical Endocrinology and Metabolism. 98 (12): 4565–4592. doi:10.1210/jc.2013-2350. ISSN 1945-7197. PMC 5399492. PMID 24151290.

Medicamentos antiandrógenos. Estos medicamentos bloquean el efecto de los andrógenos y ayudan a reducir la caída del cabello, el crecimiento del vello facial y corporal y el acné. No están aprobados por la Administración de Alimentos y Medicamentos (FDA, por sus siglas en inglés) para el tratamiento de los síntomas del SOP. Estos medicamentos también pueden generar problemas durante el embarazo.


Complementary medicine (CM) use by women has increased during the past ten years [7–11] with rates of use ranging between 26% and 91% [8, 9]. One of the popular types of CM is herbal medicine [11, 12]. Herbal medicines are known to contain pharmacologically active constituents with physiological effects on female endocrinology and have been positively associated with reduced incidences of breast cancer, osteoporosis and cardiovascular disease [13–18].

SA, JA, CS and AB conceived of the study and participated in its design and coordination. SA carried out the search of the literature. SA, JA and CS participated in study inclusion or exclusion. SA performed data extraction and CS, JA and AB reviewed the quality of data. SA, JA and AB designed and edited the tables. All authors read and approved the final manuscript.
Milewicz A, Gejdel E, et al. [64] Randomised placebo controlled, double blind, trial. Three months. 52 women with latent hyperprolactinaemia and luteal phase defects. Participants stratified for cycle length, height (cm) and weight (kgs) and randomised. Baseline differences between arms were not significant p = 0.63, p = 0.48 and p =0.37 respectively. 37 complete case reports: Treatment arm n = 17, placebo n = 20. Vitex agnus-castus extract 20 mg in the commercial preparation of Strotan® Hersteller: Pharma Stroschein GmbH, Hamburg, Germany. 1 capsule per day or placebo. Serum prolactin concentration at 15 and 30 minutes following intra venous TRH (200mcg) stimulation. Luteal phase length, number of days. Measurements on menstrual cycle days 5 to 8 and 20 for FSH, LH, oestradiol, progesterone, DHEAs, thyroid stimulating hormone (TSH), T3, T4, testosterone. No significant changes in prolactin before and after in either group. In this study 52 women were eligible to participate, statistical analyses were performed on data from 37 women.
Fertility Treatments: Once other possible reasons for infertility in you and your partner have been ruled out, your gynecologist or fertility specialist may recommend the drug clomiphene (Clomid) to induce ovulation. Six months of treatment has been known to achieve successful pregnancies for about 20-40% of women with PCOS,19 according to ACOG. If clomiphene is tried and isn’t effective, you may be given gonadotrophins to try and jumpstart your ovaries.
A stroll around the block with your dog (spouse/significant other, neighbor, or exercise buddy), your favorite exercise class at the gym, following a video at home, or peddling on an exercise bike while you watch TV…whatever you choose to get you moving will be good.14 Aim to fit in at least 30 minutes, five times a week – the basic recommendations from the US Centers for Disease Control and Prevention.15
Herbal medicine may present a treatment option for women with oligo/amenorrhoea, hyperandrogenism and PCOS as an adjunct or alternative treatment to pharmaceuticals with a high degree of acceptability by women with PCOS [6]. Preliminary evidence for equivalent treatment effects were found for the two pharmaceuticals and three herbal medicines. These were bromocriptine, in the management of hyperprolactinaemia andVitex agnus-castus and clomiphene for infertility and ovulation induction and Cimicifuga racemosa and Tribulus terrestris. Herbal medicine had positive adjunct effects with the pharmaceuticals Spirinolactone in the management of hyperandrogenism (Glycyrrhiza Spp.), and clomiphene for PCOS related infertility (Cimicifuga racemosa). It is important however to highlight that evidence was provided by a limited number of clinical studies, some with significant risks for bias; particularly Tribulus terrestris, Glycyrrhiza glabra alone and in combination with Paeonia lactiflora and Paeonia lactiflora in combination with Cinnamomum cassia.
A team approach involving care by primary care and subspecialist physicians can be helpful to address the multiple manifestations of the syndrome. Goals for treatment (e.g., treating infertility; regulating menses for endometrial protection; controlling hyperandrogenic features, including hirsutism and acne) must account for the patient's preferences because therapy selection may otherwise conflict with outcomes that the patient considers important. Metabolic complications should be addressed in every patient via a blood pressure evaluation, a lipid panel, and a two-hour oral glucose tolerance test. Patients who are overweight should be evaluated for signs and symptoms of obstructive sleep apnea. All patients should be screened for depression (Figure 119).
Clomiphene is an ovulation induction agent that has been used and studied in patients with and without PCOS.6–8,15,35,36 Studies have found that letrozole (Femara) regulates ovulation and improves pregnancy rates in women with PCOS6,37,38; however, this use is controversial because the drug is FDA pregnancy category D. It is embryotoxic and fetotoxic in animal studies, and there are no studies in pregnant women.
Si tienes un acné grave como síntoma del síndrome de ovario poliquístico, este podría mejorar si parte de tu tratamiento incluye los anticonceptivos orales o los antiandrógenos. Si tu acné no mejora tras el tratamiento, tu médico te podría remitir a un dermatólogo para que te lo trate. El dermatólogo también podría recomendarte medicamentos para reducir el oscurecimiento de la piel y para prevenir el crecimiento excesivo del vello.
When a woman isn’t ovulating regularly, the lining of her uterus (the endometrium) isn’t being exposed to the normal patterns of estrogen and progesterone. With no progesterone exposure, the lining won’t shed completely (when it sheds, that’s what women see as their period). “If this goes on, a woman can develop endometrial hyperplasia and even endometrial cancer,” she adds. (Endometrial hyperplasia is when the lining of the uterus is abnormally thick, most likely due to estrogen without progesterone exposure, and it can lead to uterine cancer.) (3)
The principle infertility treatment initially includes preconception guidelines and the use of drugs to induce mono- or bifollicular ovulation. Other therapeutic modalities may also be employed, such as exogenous gonadotropins or laparoscopic ovarian drilling, which are considered to be second-line treatments, or in vitro fertilization (IVF), which is a third-line treatment 9. Thus, the choice of the most appropriate treatment depends on the patient's age, presence of other factors associated with infertility, experience and duration of previous treatments and the level of anxiety of the couple.
Clinical investigations found no adverse effects for the six herbal medicines included in this review (Table 2). A comparative study investigating the pharmaceutical Bromocriptine and the herbal medicine Vitex agnus-castus found no side effects associated Vitex agnus-ca stus compared to 12.5% of participants taking Bromocriptine reporting nausea and vomiting [63]. No studies comparing the effectiveness for herbal medicines and the oral contraceptive pill in PCOS, oligo/amenorrhoea and hyperandrogenism were found.

Treatment of polycystic ovary syndrome is individualized to treat prevailing signs/symptoms and generally focused on correcting irregular bleeding from the uterus, restoring fertility, improving the skin manifestations of androgen excess (hirsutism, acne, hair loss), and preventing diabetes and cardiovascular disease. More recently, attention has also focused on improving the quality of life in PCOS women who have body image concerns.
on bond? he wasn't given bail so there's no way he's on bond. he was ROR'd, he's fine. he's not going to be drug tested until he is sentenced to probation or a mandatory drug program. this will be adjourned and will drag out for at least 6 months, maybe more. he won't need to even think about getting clean until he's sentenced. and he won't be doing any jailtime.
Medical management of PCOS is aimed at the treatment of metabolic derangements, anovulation, hirsutism, and menstrual irregularity. The use of insulin-sensitizing drugs to improve insulin sensitivity is associated with a reduction in circulating androgen levels, as well as improvement in both the ovulation rate and glucose tolerance. [3] The Endocrine Society has published a clinical practice guideline on hirsutism evaluation and treatment in premenopausal women. [51] ACOG notes that eflornithine in conjunction with laser treatment is superior to laser therapy alone in treating hirsutism. [3]
Unfortunately, awareness of the condition is not widespread and many physicians do not perform the necessary diagnostic tests or recognize that PCOS has broad and potentially devastating consequences. According to the non-profit support organization, PCOS Challenge, Inc., PCOS awareness and support organizations receive less than 0.1 percent of the government, corporate, foundation, and community funding that other health conditions receive.
“It’s a frustrating, difficult, and sometimes heartbreaking thing to deal with,” Eaton said. Eaton’s PCOS has given her male-pattern baldness, acne, obesity, and skin tags. In spite of her challenging symptoms, she dances and works out several times a week. “There aren't many women who look like me who can get on the floor and move like I do, who are comfortable enough in their skin to step into the spotlight and demand that people look at them,” she said.
The prevalence of depression in women with polycystic ovary syndrome (PCOS) is high; a study has shown it to be four times that of women without PCOS. Therefore, systematic evaluation of the effectiveness and safety of antidepressants for women with PCOS is important. We found no evidence to support the use or non‐use of antidepressants in women with PCOS, with or without depression. Well‐designed and well‐conducted randomised controlled trials with double blinding should be conducted.
OGTT with 75-g glucose and hourly glucose and insulin measurements has been compared to clamp techniques. Insulin sensitivity calculated by mathematical transformation of measurements has shown good correlation with glucose disposal using clamp techniques[48]. Although the OGTT is easy to perform, these calculations are more complex and make this particular calculation less desirable for clinical use. However these data show that 1 and 2 h levels are often needed to diagnose IR and stress the potential for false negative results with fasting measurements alone. In patients undergoing clamp and OGTT no correlation was observed between fasting glucose/insulin ratios and IR on the clamp[48].
On June 8, 2011, the FDA notified health care professionals of its recommendations for limiting the use of the highest approved dose (80 mg) of the cholesterol-lowering medication simvastatin (Zocor) because of increased risk of muscle damage. The FDA required changes to the simvastatin label to add new contraindications (should not be used with certain medications) and dose limitations for using simvastatin with certain medications. [64]
Polycystic ovarian syndrome is classified as a disorder which encompasses a group of symptoms that collectively indicate a distinct health issue. This means that the symptoms associated with PCOS will vary from woman to woman. Your PCOS experience is probably very different from another woman with this condition but that does not mean you are alone! PCOS is a condition which can affect between 5 – 10% of all women and is the most common cause of infertility.8 You may be wondering how you ended up in this group of women but unfortunately the precise reason polycystic ovarian syndrome develops isn’t completely clear. 8 Having said that, many experts believe insulin as well as hormone imbalances have a strong influence on PCOS and the severity of its symptoms.
El estilo de vida puede tener un gran impacto en la resistencia a la insulina, especialmente si una mujer tiene sobrepeso debido a su dieta o a la falta de actividad física. La resistencia a la insulina también es un rasgo de familia. Perder peso ayudará muchas veces a mejorar los síntomas, independientemente de lo que causó la resistencia a la insulina.
This led the researchers to experiment with blocking the body from responding to this excess GnRH. They treated a separate group of pregnant mice with AMH but also another drug that blocks the body from responding to the higher levels of GnRH (called a “GnRH antagonist”). They followed the daughter pups born to these mothers, and turns out they didn’t develop PCOS-like symptoms! They also wanted to see if they could give GnRH antagonist to daughter pups who had already developed PCOS-like symptoms (because their mothers only received high levels of AMH while pregnant). After treatment with the GnRH antagonist, the daughter pups’ hormone levels started to normalize and they ovulated more than those who didn’t get the antagonist treatment.
A secondary analysis of two randomized, double blind, placebo-controlled trials that included 182 children of mothers with PCOS reported that children exposed to metformin had higher BMI and increased prevalence of overweight/obesity at 4 years of age. The study found that at 4 years of age, the metformin group had higher weight z-score than the placebo group; difference in means 0.38 (0.07 to 0.69), p=0.017, and higher BMI z-score; difference in means 0.45 (0.11 to 0.78), p=0.010. There were also more overweight/obese children in the metformin group; 26 (32%) than in the placebo group; 14 (18%) at 4 years of age; odds ratio (95% CI): 2.17 (1.04 to 4.61), p=0.038. More studies are needed to examine this association. [94]
Bilang kababaihan edad, iba't-ibang mga genetic at hormonal disorder nakakaapekto sa kanilang buhay at kalusugan. Isa tulad ng hormonal kawalan ng timbang na may kaugnayan disorder na nakakaapekto sa mga kababaihan ay Polycystic Ovarian Syndrome (PCOS). Sa ganitong syndrome, dahil sa isang kawalan ng timbang sa mga reproductive hormones, likido-punong cysts punan ang obaryo. Ang mga obaryo makakuha pinalaki at itigil ang gumagana nang normal (1, 2).
Dr. Annie Morrissey is Board Certified in endocrinology.  She earned her medical degree from Memorial University of Newfoundland.  She completed her internal medicine residency at Mayo Clinic in Rochester, MN and her endocrinology fellowship at Washington University in St. Louis, MO.  Prior to NCH she practiced in Columbia, TN.  She is a member of the American Diabetes Association, Endocrine Society, and American Association of Clinical Endocrinologists
Hi dok..may tanung lang po ako..kasi po almost 9 months napo akung d nireregla..dati po kasi nagpatingin nku sa ob gyne at niresetahan ako ng contraceptive pills ung diane 35. Siguro po 3 months din ako uminom nun..at niregla din nman po ako…tinigil ko lang po kasi un kasi po sabi ng matatanda bat daw po ako umiinom ng pills eh wala pa daw po akung anak at asawa bka daw po mas lalong masira matress ko..ano po ba dapat kung gawin .takot kuna po kasing magpatingin sa doktor ulit…sana rwplayan nyo po ako.tnx pi
The authors hypothesized that something might be going on in the maternal environment in the womb that was causing PCOS in daughters. To get to the bottom of it, the authors first studied pregnant women by measuring a hormone call anti-Mullerian hormone (AMH). Usually, in pregnancy, a women’s AMH levels decrease. But the authors noticed that in women with PCOS, their levels of AMH did not decrease. The next step was to figure out what these high AMH levels might be doing to the daughters of women with PCOS. The authors used mice to model what was happening with human women by treating pregnant mice with AMH. When they were born, the pups of the treated mice had a lot of the same symptoms as women with PCOS: anovulation, higher testosterone levels, fewer litters and fewer pups per litter, among others. They also noticed that the brains of the mouse mothers treated with AMH produce a lot of another hormone, called GnRH. In fact, they produced three times the amount that control mouse mothers did.
Sa artikulong ito, dapat naming makipag-usap tungkol sa mga syndrome, mga sanhi nito, at sintomas, ang mga iba't ibang mga remedyo sa bahay na maaari mong subukan, at din ang ilang maingat mga panukala na maaari mong idaos. Bigyan ito ng isang read! Hindi mo alam kung ano ang lunas ay maaaring talagang nag-click para sa iyo at nag-aalok ng ilang mga kaluwagan.
If he was using heroin very heavily, that may well be his starting methadone dose (or close to it.) Methadone has a long half life while heroin has a short one, so avoiding withdrawals can take a lot of methadone, initially. Methadone clinics aren't going to leave someone on a high dose though. They'll titrate up until withdrawal subsides, then taper down over time. I'm guessing he started at the clinic around when he got busted, so it's sus af to me that he'd still be taking 130mg. Or that he ever was. Maybe 100. Possibly.

Diet, exercise, and maintaining a healthy body weight may help many women manage the symptoms of PCOS. These lifestyle changes are recommended to help decrease insulin resistance. Weight reduction can also decrease testosterone, insulin, and LH levels. Regular exercise and healthy foods will help lower blood pressure and cholesterol as well as improve sleep apnea problems. Refraining from smoking cigarettes or other tobacco products also may lower androgen levels.
she's mentioned before that "healthy foods" are "rich people foods" which is just total bullshit to anyone who's gone grocery shopping. she used to post cvs hauls of frozen pizzas and candy she'd get for herself and lurch and it would be one nights worth of food. cvs is overpriced as fuck but even at a normal store, buying exclusively prepackaged junk food is expensive as fuuuccck. buy some rice and beans.
Chicken and egg: was Luna an asshole who started drugs and became even more of an asshole, or did she start drugs that turned into an asshole? A lot of what's wrong with her has little to do with her addiction - e.g. her desperate attempts at focusing everything into a mad scramble for sympathy (some bum died, so she wrote a story that made it look as if he had been her closest friend so people tell her they're sorry etc.) derive from her being an asshole, not from her addiction. Anyone who consciously wants to become a junkie for an aesthetic is already way deeply fucked imho.
I think it's more than likely she tries to avoid her dad thinking she's in a bad situation, financially or otherwise - because then he'd do something evil like try get her help or buy her food instead of lipsticks. I think she pretends everything's fine to him, but that all her money goes on rent, so he treats her to shopping trips and pampering every time she visits, believing the rest of the time she's actually using her time productively and making rent payments, meanwhile she's playing the "I'm so poor please help" card with everyone else. She's playing everyone of each other.

Los ovarios de la mujer tienen folículos, que son los sacos diminutos y llenos de líquido que contienen los óvulos. Cuando el óvulo madura, el folículo lo libera para que pueda desplazarse al útero para la fertilización. En mujeres con el síndrome, los folículos inmaduros se agrupan y forman quistes o bultos grandes. Los óvulos maduran con los grupos de folículos, pero los folículos no se abren para liberarlos.


Habang remedyo sa bahay ay maaaring maging isang mahusay na pagpipilian para sa paggamot ng PCOS, naghahanap ng medikal na tulong ay din napakahalaga sa karamihan ng mga oras. Makipag-usap sa iyong doktor tungkol sa iyong mga plano upang bigyan ng bahay remedyong subukan mo upang ang mga pinakamahusay na posibleng mga kumbinasyon ng paggamot ay maaaring devised para sa iyo. Gayundin, PCOS ay madalas na nauugnay sa isang hindi malusog lifestyle at diyeta. Para sa ito, kami ay compiled ng isang listahan ng mga maingat mga panukala na maaari mong sundin upang labanan ang kundisyong ito.
Muchas gracias por tu comentario 🙂 Efectivamente, PCOS tiene como objetivo ayudar a regular los niveles que están desajustados en las mujeres con SOP. De esta forma, contribuye a que las reglas se regulen de forma natural y se alivien otros síntomas del SOP. PCOS es eficaz en 8 de cada 10 mujeres y suele regular los ciclos tras 2/3 meses tomándolo.

Mammalian ovary development undergoes important changes during the perinatal period, moment when follicles are assembled and start to develop in a process not well known, involving endocrine and paracrine factors. In order to investigate the effect of two different hormonal environments on the early development of the ovary, we used an autologous transplant model in which Syrian hamster fetal ovaries were grafted under the kidney capsule of males hosts previously unilaterally or bilaterally orchidectomized. After 35 days of graft, ovaries and kidney parenchyme of the host male did not present signs of rejection. Ovaries contained primordial, primary follicles, secondary follicles and few tertiary follicles with morphological features similar to ovaries of control females of 35 days of age. Healthy primary and secondary follicles of experimental groups had frequency distribution and size similar to control ovaries but tertiary follicles were scarce in control as well as in grafts where they were mainly atretic. PCNA, marker of proliferation, was immuno detected in granulosa cells of growing follicles and the marker of apoptosis, Caspase 3 active, was evident mainly in secondary follicles. Immunoreactivity for steroidogenic proteins, StAR, 3-βHSD and aromatase detected in the follicular wall cells and the decreased serum levels of FSH without important changes in testosterone in bilateral orchidectomized males that received ovarian graft, and testosterone decreased without changes in FSH levels in unilateral orchidectomized males (UO) with ovarian graft, all together suggest the effect of steroid hormones produced by the ovary. In conclusion, the experimental model of autologous transplant presents evidence of early ovary development under the kidney capsule and its functional integration to the endocrine axis of the host male.
Reproductive dysfunction in PCOS women may also be a manifestation of IR. Menstrual cycle irregularity has been correlated with HOMA-IR[37]. Molecular defects in insulin action may be responsible for reproductive difficulties in PCOS women. Although endometrial tissue appears morphologically similar in PCOS to controls and may have similar insulin receptor prevalence, insulin receptor action at the local endometrial level is impaired and may be reflected in lower pregnancy implantation rates[38]. HOMA-IR has been correlated with follicle count in PCOS during in vitro fertilization[39]. Follicular insulin levels correlate with pregnancy outcome after IVF[40]. These are areas of unresolved understanding with regard to PCOS. Proposed mechanisms for insulin reproductive abnormalities include abnormalities of ovarian steroidogenesis, excessive LH secretion and abnormalities in glucose uptake[41]. PCOS women have been found to have post-receptor insulin abnormalities as well as reduced peripheral insulin receptor binding[42].
130mg of methadone?!!!! That's 520mg morphine. That's an insane dosage even for someone with tolerance - I have been on high dose opioids for pain for a decade and I'm scraping 250mg morphine equivalent dose. For context: the equivalent fentanyl patch would be 250mcg per hour strong. Even people with severe pain from tumours get by on no more than 100-150mcg per hour.
If I were the nurse I wouldn't fucking care either. When an insane person or an addict is shitting and pissing all over the floor, all they can do is give them a bucket, qurantine them and clean it up after they're done. Nurses are human, plenty of them gag at the smell and sight of shit and vomit, just like everyone else. Just because they clean it up doesn't mean they enjoy doing it.

Polycystic ovary syndrome (PCOS) can be a daunting diagnosis to receive. The National Polycystic Ovary Syndrome Association defines the condition as a “genetic, hormonal, metabolic, and reproductive disorder that affects women.” (1) One in 10 women have it (about half don’t know it), and the complications can include infertility, obesity, and mood disorders.
Hyperinsulinemic-euglycemic clamp techniques rely on an intravenous insulin infusion to maintain steady serum glucose concentrations at fasting levels to measure glucose uptake. Lower glucose uptake signifies resistance to insulin action (i.e. IR). Since the technique requires intravenous infusions, frequent blood sampling, extensive time and significant financial resources, it is experimentally useful but clinically cumbersome[45]. Clamp studies in PCOS women show conflicting results; some studies show IR only in obese PCOS women[46] and others demonstrate IR in lean PCOS patients[47]. Of importance, the studies which failed to demonstrate IR in lean PCOS women did, however, demonstrate elevated basal insulin levels compared to weight matched, non PCOS controls[46]. Other sophisticated testing methods using intravenous infusions of insulin have been attempted (insulin sensitivity test and insulin tolerance test) but they do not alleviate the time, financial and testing burdens to make them relevant for widespread clinical practice and normal cutoffs are not widely disseminated[45]. Clamp techniques have been used as comparisons to validate other modes of assessment of IR.
This is a great place for any event: there is a restaurant area for lunches and dinners, small tables for romantic evenings, a lounge area equipped with comfortable sofas and low tables, as well as a huge bar and a dance floor. AQUA LUNA’s summer terrace offers a splendid view onto the yacht club, the spires and roofs of the medieval Old Town, Vanšu Bridge, and modern business buildings – it is the ideal place to enjoy sunshine during the day, sunsets in evenings, and moonlight. In colder weather, AQUA LUNA warms hearts with its cosy atmosphere during long dinners by the fireplace and cheerful weekend parties.
Reglan Active ingredient: metoclopramide $0.37 for pill Reglan is used for short-term treatment of gastroesophageal reflux disease (GERD) in certain patients who do not respond to other therapy. It is used to treat symptoms of a certain digestive problem in diabetic patients (diabetic gastroparesis). Prilosec Active ingredient: omeprazole $0.49 for pill Prilosec relieves symptoms of gastroesophageal reflux disease decreasing the amount of acid in the stomach.
Regular menstruation is important for the prevention of endometrial cancer. Women with PCOS are three times more likely to have endometrial cancer than women without. When a woman isn’t menstruating on a frequent basis, the lining of the uterus (endometrium) can begin to grow excessively and undergo atypical cell changes resulting in a precancerous condition called endometrial hyperplasia. If left untreated, this can develop into full endometrial cancer. Hormonal birth-control pills are often prescribed to help women with PCOS shed their endometrium more regularly, an important measure for preventing the overgrowth of cells in the uterus.

The differential diagnosis of PCOS is broad and includes both endocrinologic and malignant etiologies. Figure 119 provides an algorithm for the workup of select presentations. For any woman with suspected PCOS, the Endocrine Society recommends excluding pregnancy, thyroid dysfunction, hyperprolactinemia, and nonclassical congenital adrenal hyperplasia.19 Depending on presentation, conditions such as hypothalamic amenorrhea and primary ovarian insufficiency should also be excluded. In women with rapid symptom onset or significant virilization, such as deepening voice or clitoromegaly, an androgen-secreting tumor should be ruled out. Finally, Cushing syndrome or acromegaly should be excluded in patients with physical findings that suggest either condition.19 There is no need to order laboratory testing for these conditions if the patient does not have suggestive physical findings.

That pic in the last thread with her collarbones made me laugh so much. Bitch has her arms bent at an awkward angle behind her back you can see where the neck squashes awkwardly on her shoulder because of the abnormal way shes twisting and sticking her neck out. Imagine being a fly on the wall at hers (one of the many) and seeing her take a selfie like that kek


Walang taning na gamot na magagamit sa merkado upang maiwasan ang PCOS. Medikal na eksperto magmungkahi na ang mga apektadong mga kababaihan ay dapat resort sa ilang mga mahahalagang pamumuhay at pandiyeta pagbabago upang makaya sa mga ito. Dahil ito ay una ng isang hormone na may kaugnayan disorder, eradicating ang mga ugat ng hormonal kawalan ng timbang ay maaaring dalhin ang nais na resulta. Ang ilang mga natural na mga remedyo kontrolin ang nakapailalim na mga kadahilanan habang ang ilang mga iba asintahin pag-aalis ng mga sintomas. Hanapin sa ibaba ang mga remedyo sa bahay upang tratuhin ang PCOS.
Our laboratory search included investigations into the effects of herbal medicine using computer models, cell cultures, animals with PCOS induced with oestradiol valerate and androgens and sterilised and ovariectomised rats. We excluded laboratory studies which commenced using isolated chemicals not directly extracted from crude herbal medicines and studies examining androgen effects in male animals.
Polycystic ovary syndrome represents 80% of anovulatory infertility cases. Treatment initially includes preconception guidelines, such as lifestyle changes (weight loss), folic acid therapy to prevent the risk of fetal neural tube defects and halting the consumption of tobacco and alcohol. The first-line pharmacological treatment for inducing ovulation consists of a clomiphene citrate treatment for timed intercourse. The second-line pharmacological treatment includes the administration of exogenous gonadotropins or laparoscopic ovarian surgery (ovarian drilling). Ovulation induction using clomiphene citrate or gonadotropins is effective with cumulative live birth rates of approximately 70%. Ovarian drilling should be performed when laparoscopy is indicated; this procedure is typically effective in approximately 50% of cases. Finally, a high-complexity reproduction treatment (in vitro fertilization or intracytoplasmic sperm injection) is the third-line treatment and is recommended when the previous interventions fail. This option is also the first choice in cases of bilateral tubal occlusion or semen alterations that impair the occurrence of natural pregnancy. Evidence for the routine use of metformin in infertility treatment of anovulatory women with polycystic ovary syndrome is not available. Aromatase inhibitors are promising and longer term studies are necessary to prove their safety.

If you’ve been told you have PCOS, you may feel frustrated or sad. You may also feel relieved that at last there is a reason and treatment for the problems you have been having, especially if you have had a hard time keeping a healthy weight, or you have excess body hair, acne, or irregular periods. Having a diagnosis without an easy cure can be difficult. However, it’s important for girls with PCOS to know they are not alone. Finding a health care provider who knows a lot about PCOS and is someone you feel comfortable talking to is very important. Keeping a positive attitude and working on a healthy lifestyle even when results seem to take a long time is very important, too! Many girls with PCOS tell us that talking with a counselor about their concerns can be very helpful. Other girls recommend online chats. The Center for Young Women’s Health offers a free and confidential monthly online chat for girls and young women with PCOS.
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