Fasting methods to measure IR have been advocated for many years as an adjunct to DM screening. Elevated fasting insulin levels greater than 20 μU/mL may alone indicate IR. Fasting glucose/insulin ratio (G/I) has also gained some clinical traction. A ratio < 4.5 has in general been shown to be > 90% sensitive in some populations[45] but has never been validated with clamp studies[48]. Some ethnic variation in G/I cutoff ratios may exist[49]. There has been some suggestion that G/I < 7 in very young girls may predict IR[50,51].


Certain lifestyle changes, such as diet and exercise, are considered first-line treatment for adolescent girls and women with polycystic ovarian syndrome (PCOS). [41] Pharmacologic treatments are reserved for so-called metabolic derangements, such as anovulation, hirsutism, and menstrual irregularities. Medications for such conditions include oral contraceptives, metformin, prednisone, leuprolide, clomiphene, and spironolactone.
This therapeutic modality is also considered a second-line treatment for the infertility of women with PCOS. However, because it is an invasive method that requires general anesthesia and has a higher cost and potential complications, this technique should be used in cases of anovulatory women with CC-resistant PCOS who require laparoscopy for another reason (pelvic pain, adnexal mass, etc.). This technique can be performed using monopolar electrocautery or laser techniques, with both exhibiting a similar efficacy and the goal is between 4 and 10 punctures because a larger number may favor the development of premature ovarian failure 25,29. The mechanism of action of ovarian drilling in the treatment of infertility in women with PCOS is suggested to be based on the decreased secretion of androgens and consequent reduction of peripheral aromatization of these compounds into estrone. Furthermore, the follicular microenvironment becomes more estrogenic, which facilitates follicular growth 30. Regarding the efficacy of ovarian drilling, observational studies demonstrated that the ovulation rate was between 54 and 76% in the 6 months after the procedure and 33 and 88% in the 12 months after the procedure. During these periods, the spontaneous pregnancy rate ranged between 28 and 56% and 54 and 70%, respectively 31.
Shahin [68] Non-blinded randomised controlled trial. Women with PCOS and infertility, n = 194. All participants received pharmaceutical ovulation induction (Clomiphene citrate 150 mg on days 3–7 of cycle); trigger injection (HCG 10000 IU Pregnyl), timed intercourse and progesterone support (oral micronized progesterone). A randomly selected group additional took Cimicifuga racemosa 120 mg per day (Klimadynon®) Primary outcomes pregnancy rates. Secondary outcomes: Pregnancy rates were 33 out of 192 cycles (17.2%) for the clomiphene alone group and 71 out of 204 cycles (34.8%) for the clomiphene plus Cimicifuga racemosa group. Non-blinding compromised the internal validity of the findings in this study. Confounding variables include variations in participant’s and clinicians attitudes and may have led to differences which were unaccounted for between the two groups. However the outcomes are objective with a statistically powered sample size.
Oh ffs Tuna, Courtney Love was a dirty junkie but she had style that was her own and in some of her brighter moments really knew how to dress herself. She also had talent (although i do think some farmers might disagree) - the heroin aesthetic doesn't really work if you're just a lazy do nothing that spends your days cuddling with filthy hello kitty dolls and taking pictures of your raggedy trash outfits. Go learn how to play the guitar and stop whining.
I've never believed that she could get together $1700 on rent ALONE. I don't know much about U.S benefits but in the UK for an under 25 year old unemployment check is just about £60 a week. Even disability allowance wouldnt support the cost of a house like that and their drug habit. Seems impossible that they'd be paying for the house without help from Roger or family members
96. Glintborg D, Frystyk J, Højlund K, Andersen KK, Henriksen JE, Hermann AP, Hagen C, Flyvbjerg A, Andersen M. Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic ovary syndrome. Clin Endocrinol (Oxf) 2008;68:165–174. [PubMed]
Maybe anons theory of them using Roger's potential ssi funds for rent isn't to far off? My grandpa used to get like 1200 a month from ssi but it's probably gone up since then and if they get some sort of housing assistance usually they would only have to pay 1/3 of their income. Which would leave plenty to live off of comfortably for the month unless you are using your funds for drugs or useless amazon crap like tuna buys
This therapeutic modality is also considered a second-line treatment for the infertility of women with PCOS. However, because it is an invasive method that requires general anesthesia and has a higher cost and potential complications, this technique should be used in cases of anovulatory women with CC-resistant PCOS who require laparoscopy for another reason (pelvic pain, adnexal mass, etc.). This technique can be performed using monopolar electrocautery or laser techniques, with both exhibiting a similar efficacy and the goal is between 4 and 10 punctures because a larger number may favor the development of premature ovarian failure 25,29. The mechanism of action of ovarian drilling in the treatment of infertility in women with PCOS is suggested to be based on the decreased secretion of androgens and consequent reduction of peripheral aromatization of these compounds into estrone. Furthermore, the follicular microenvironment becomes more estrogenic, which facilitates follicular growth 30. Regarding the efficacy of ovarian drilling, observational studies demonstrated that the ovulation rate was between 54 and 76% in the 6 months after the procedure and 33 and 88% in the 12 months after the procedure. During these periods, the spontaneous pregnancy rate ranged between 28 and 56% and 54 and 70%, respectively 31.
One strategy that may help some of you: Have a big breakfast. When a group of normal weight women with PCOS got a whopping half of their daily calories first thing in the morning, insulin levels dropped 8% and testosterone levels fell 50% in three months.13 And that’s not all. These women ovulated more frequently and had improved insulin sensitivity in comparison to another group of women in the study who more of their calories at dinner.13

Women with an abnormal lipid profile should be counseled on ways to manage the dyslipidemia. Such measures include eating a diet low in cholesterol and saturated fats and increasing physical activity. Guidelines from the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III, or ATP III) (2001) serve as a guide for the treatment of women with PCOS and dyslipidemia. The NCEP is currently updating the ATP III guidelines; Readers are encouraged to check the National Health Lung and Blood Institute Web site for the most recent guidelines: http://www.nhlbi.nih.gov/guidelines/cholesterol/atp4/index.htm.

PCOS is a heterogeneous disorder of uncertain cause.[23][24] There is some evidence that it is a genetic disease. Such evidence includes the familial clustering of cases, greater concordance in monozygotic compared with dizygotic twins and heritability of endocrine and metabolic features of PCOS.[7][23][24] There is some evidence that exposure to higher than typical levels of androgens in utero increases the risk of developing PCOS in later life.[25]


yeah, the constant nitpicking about things she can't help is annoying. people are desperate for milk so they'll try to make a topic out of everything. for example, that anon who was saying how gross her arm looks because it has stretch marks and loose skin. what's she supposed to do about that? shes a shitty person but i gaurentee none of the anons on this thread are perfect or even attractive enough to be such nitpickers
hi doc bru ! ask ko lng po 7 years na po kami nagsasama ng asawa ko nagpafertility check naman po kami 2 years ago . ok nman po sperm count nia at ok nman din po ung ultrasound ko may nakita lng po na maliliit na bukol sa uterus ko . niresetahan po ako ng metmorfin fertyl at folic acid. regular nman po 28 days ung cycle ko! pero until now ndi pa din po kami nakakabuo . ano po ba the best way na gawin namin para magkababy na? i hope po na masagot nio .. thankyou en godbless po

Although there isn’t a single cure for PCOS, lifestyle and nutritional changes can significantly improve the hormonal imbalances that are so prevalent in PCOS. Weight loss and exercise will reduce the levels of insulin and targeted nutritional supplements can help balance out the systemic biochemistry. A healthy lifestyle is the best medicine and through a comprehensive and consistent improvement in diet and activity, PCOS symptoms can be effectively managed or diminished, and some can be made to disappear completely.

Hirsutism: On the complete other end of the spectrum as hair loss, women who have hirsutism experience excess hair growth in oftentimes very noticeable places, such as their face, chest, and back. This is also a very embarrassing issue for women to cope with in their daily life. According to research experts, “hirsutism appears to be strongly related with hyperandrogenism (imbalance of male sex hormones) and metabolic abnormalities in PCOS women.”4
There have been many studies on PCOS in the past several years; however, most are fairly small. Also, many studies examine medication effects on surrogate markers (e.g., androgen levels) rather than clinical outcomes (e.g., hirsutism). The study results are often conflicting, and in a recent systematic review, only 33 of 115 possible studies met basic inclusion criteria (e.g., randomized controlled trials), suggesting that many of the data in the literature may have methodologic flaws.1
PCOS ay nagpapahiwatig sub-optimal gumagana ng reproductive organo. Kathang isip ng isang bata ay itinuturing na mahirap na sa ilalim ng gayong mga kalagayan. At kahit na kung ang babae ay maglihi, mga pagkakataon ng mga komplikasyon ng pagbubuntis at paghahatid ay mataas. Pagkalaglag, preeclampsia, gestational diabetes, at preterm kapanganakan ay napaka-pangkaraniwan. Wastong pag-aalaga at tamang gamot ay maaaring makatulong sa pagbubuntis upang maging isang makinis na paglalakbay. Kumonsulta sa iyong doktor kung ikaw ay nagpaplanong magbuntis at sundin ang kanyang / ang kanyang mga rekomendasyon mabuti.

In vitro fertilization (IVF). IVF may be an option if medicine does not work. In IVF, your egg is fertilized with your partner's sperm in a laboratory and then placed in your uterus to implant and develop. Compared to medicine alone, IVF has higher pregnancy rates and better control over your risk of having twins and triplets (by allowing your doctor to transfer a single fertilized egg into your uterus).
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