Wang et al. 2008 [66] Double blinded, placebo controlled randomised trial (pilot). Eight weeks. 15 overweight women with oligo/amenorrhoea and polycystic ovaries on ultrasound. Mean body mass index 28.8 ± 1.3 kg/m2. Mean age 31.1 ± 2.0 years Cinnamomum cassia extract 333 mg (Integrity Nutraceuticals International Sarasota, Florida) or placebo. One tablet three times per day. Primary outcomes: Insulin resistance and sensitivity. Secondary outcomes oestradiol and testosterone concentration. Body mass index (BMI). Before and after treatment comparisons between randomised groups plus comparison between treatment group and normal ovulatory, normal weight women. Adverse events. Improved insulin sensitivity (QUICKI) in the treatment group. 0.35 to 0.38, (7.7%) p < 0.03. Insulin resistance (HOMO-IR) significantly reduced in treatment group 2.57 to 1.43 (44.5%) p < 0.03. Controls no change insulin sensitivity or insulin resistance. No change in either group for BMI, testosterone and oestradiol. Differences between Cinnamomum cassia group and normal weight and ovulatory controls were not significant. (P < 0.17). No reported adverse reactions. Small pilot study, the authors report that larger studies are required to confirm findings. Small sample size may explain non-significant comparison with normal weight and ovulating women. Reproductive outcomes were unchanged in this study however the duration of the study was insufficient to demonstrate reproductive changes.
Gymnema (Gymnema sylvestre) This is a common herb used in traditional Ayurvedic medicine and has been called the herbal form of Metformin.3 It is an anti-diabetic that is characterized by insulin modulating activity which means it regulates insulin levels while controlling sugar or carbohydrate cravings. Gymnema actually numbs the sweet taste areas of the taste buds which helps suppress appetite. Some research has indicated that this herb might stimulate production of cells in the pancreas which in turn increases the levels of insulin in the body.

Polycystic ovary syndrome (PCOS) is a set of symptoms due to elevated androgens (male hormones) in females.[4][14] Signs and symptoms of PCOS include irregular or no menstrual periods, heavy periods, excess body and facial hair, acne, pelvic pain, difficulty getting pregnant, and patches of thick, darker, velvety skin.[3] Associated conditions include type 2 diabetes, obesity, obstructive sleep apnea, heart disease, mood disorders, and endometrial cancer.[4]
Mastodynon® additionally contains herbal extracts of Caulophyllum thalictroides, Lilium majus, Cyclamen, Ignatia and Iris. Reasons were as follows; 4 due to drug reactions and 15 due to pregnancy. 15 women conceived in the treatment group compared to 8 in placebo group in the first 3 months (while women were treated). Inconsistencies in data assessment include the recommendation for treatment with Mastodynon over 3–6 months yet it was tested for 3 months.
My brother was a Heroin addict who started taking Benzos between his shooting up, like Luna, versus the other way around. He was an addict, he took benzos to keep up whatever feeling he was chasing. Thats inherently different than an anxiety or depression patient taking them for relief of symptoms. Im sure it does happen, there's always that risk but I wouldn't go out there and say that Benzo use is always a gateway.
Polycystic ovary syndrome (PCOS) is a complex, common reproductive and endocrine disorder affecting up to 17.8% of reproductive aged women [1]. Medical management places strong emphasis on a multidisciplinary approach as pharmaceutical treatments appear to be only moderately effective in treating individual symptoms [2, 3]. Conventional pharmaceutical management is limited by the prevalence of contraindications in women with PCOS [3], non-effectiveness in some circumstances [4], side effects [5] and by preferences of women with PCOS for alternatives to pharmaceutical management [6]. This review examines the mechanisms of effect for a potential alternative treatment, herbal medicine, and reveals six herbal medicines with both pre-clinical and clinical data explaining the reproductive endocrinological effects in PCOS and associated oligo/amenorrhoea and hyperandrogenism.
Results of a second study by the same research team offer doctors a clear strategy to help you lose weight.5 According to this study at Penn State Health in Philadelphia, patients who worked with their physician to follow a limited fat, low calorie diet (~1200 calories) by relying on low-calorie prepared meals (eg, SmartOnes, Lean Cuisine or Healthy Choice) and an appetite suppressant with meals and making lifestyle changes plus added fruits and vegetables.4
She is mentally ill and on tons of drugs all day long? Focusing on something shallow is doable in that kind of state. Plus she gets asspats for being cyberbullied by a mean forum lol. If she genuinely confronted the fact that she completely and utterly fucked up her life, that everything is her fault and she really just sucks as a person inside and out, she'd probably have a massive breakdown. She just numbs all of these feelings with drugs.
Obese women with PCOS may have an increased risk of congenital anomalies (heart and neural tube defects), gestational diabetes mellitus [odds ratio (OR) 2.94; 95% confidence interval (CI): 1.70-5.08], hypertensive disorders during pregnancy (OR 3.67; 95% CI: 1.98-6.81) [mainly preeclampsia (OR 3.47; 95% CI: 1.95-6.17)], miscarriages, preterm births (OR 1.75; 95% CI: 1.16-2.62), the need for intensive unit care (OR 2.31; 95% CI: 1.25-4.26), increased perinatal mortality (OR 3.07; 95% CI: 1.03-9.21) 11,12 and Caesarean delivery (OR 1.74; 95% CI: 1.38-2.11) 12. The risk for preterm births and preeclampsia appears to be associated with maternal hyperandrogenism 13.

When a woman is not menstruating or ovulating, an insufficient amount of the hormone progesterone is produced. This hormonal imbalance can lead to an overgrowth of the lining of the uterus (endometrial hyperplasia) and can increase a woman's risk of developing endometrial cancer. Women with PCOS who do ovulate and become pregnant tend to have an increased risk of complications such as miscarriage.
She thinks she's pretty much perfect, and having one thing about herself she doesn't like won't convince me that Tuna is a ~dark twisted individual full of self-hate. She clearly doesn't fit that image, and she's trying to make herself appear like that but it's 100% fake. Pic related, it's a call-out post from one of her old friends, seeing as people in here seem too newfag to know Luna's ways.
On rare instances, if I'm in a dire hurry (of the 'ward rounds start in five minutes, I haven't had a single bite to eat since yesterday 1600 and my blood sugar is tanking like Luna's mu opioid receptors' kind), and the person in front of me is taking utter eternities to count out $3.50 for a shitty sandwich or whatever the fuck they bought, I sometimes just pay for my shit and theirs so that I can go to work and listen to the Munchie crop of the day. So I've known a few people who try to game people in a hurry by doing this counting out cash trick on them. At the same time I have been pretty dubious of Luna's stories and I think that almost all the time, it's a cover for stealing.

PCOS-related hormonal dysfunction can result in irregular or absent ovulation (anovulation). A variety of drugs can be used to treat this, enhancing the quality of both the egg (oocyte) and ovulation. Typical, first-line treatments include the fertility drugs Clomid (clomiphene citrate) and Femara (letrozole). While Clomid is commonly used to enhance ovulation, Femara may work better in women with PCOS as it neither raises estrogen levels nor increases the risk of multiple births to the same degree as Clomid.
When the former NFL cheerleader Natalie Nirchi stopped menstruating at age 17, she was diagnosed with polycystic ovary syndrome (PCOS), a hormone disorder affecting up to 10 percent of women of reproductive age. She didn’t initially show any of the physical symptoms, like excess hair growth, cystic acne, or obesity, but a blood test revealed that she had high levels of testosterone and an ultrasound showed cysts on her ovaries.
Combination oral contraceptives, especially those with progestins of norgestimate, desogestrel, or drospirenone (because of their low androgenic effects), are among the most commonly used medications for hirsutism in women with PCOS.2 However, they are not approved by the U.S. Food and Drug Administration (FDA) for this use. One study found that women taking desogestrel/ethinyl estradiol (Apri) had lower hirsutism scores on a standardized scale (i.e., the Ferriman-Gallwey hirsutism score).34 Finasteride (Propecia) and flutamide (formerly Eulexin) are effective, but are FDA pregnancy categories X and D, respectively; the use of these agents for hirsutism is strictly off-label.2
PCOS is a heterogeneous disorder of uncertain cause.[23][24] There is some evidence that it is a genetic disease. Such evidence includes the familial clustering of cases, greater concordance in monozygotic compared with dizygotic twins and heritability of endocrine and metabolic features of PCOS.[7][23][24] There is some evidence that exposure to higher than typical levels of androgens in utero increases the risk of developing PCOS in later life.[25]
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