This study synthesises the evidence for reproductive endocrine effects for six whole herbal medicine extracts that may be used to treat PCOS and associated oligo/amenorrhoea and hyperandrogenism. The findings were intended to add to clinicians understanding for the mechanisms of action for herbal medicine for treatment in these common conditions and reveal herbal medicines with reproductive endocrinological effects, currently demonstrated in scientific literature.
A majority of women with PCOS have insulin resistance and/or are obese. Their elevated insulin levels contribute to or cause the abnormalities seen in the hypothalamic-pituitary-ovarian axis that lead to PCOS. Hyperinsulinemia increases GnRH pulse frequency, LH over FSH dominance, increased ovarian androgen production, decreased follicular maturation, and decreased SHBG binding. Furthermore, excessive insulin, acting through its cognate receptor in the presence of component cAMP signalling, upregulates 17α-hydroxylase activity via PI3K, 17α-hydroxylase activity being responsible for synthesising androgen precursors. The combined effects of hyperinsulinemia contribute to an increased risk of PCOS. Insulin resistance is a common finding among women with a normal weight as well as overweight women.
One of the biggest challenges in reviewing the evidence for PCOS treatment is that many manifestations of the condition may be components of other disease processes. For example, there may be a study of medications that are useful for hirsutism, but the patient population in the study did not explicitly have PCOS. Thus, recommendations specific for treating symptoms of PCOS may be lacking. When reviewing a study of the treatment of insulin resistance in a general population, it cannot be assumed that the outcomes would mirror those in women with PCOS.
I've noticed a repeating pattern with cows where someone makes an off hand comment about their appearance, which was probably more of a: "wow that looks fucking bizarre but I don't want to be flat out rude but am so baffled I still have to comment" comment. Which I assume is what happened with the angel shit. If anyone actually said that. She just misinterpreted it as a compliment.
High levels of masculinizing hormones: Known as hyperandrogenism, the most common signs are acne and hirsutism (male pattern of hair growth, such as on the chin or chest), but it may produce hypermenorrhea (heavy and prolonged menstrual periods), androgenic alopecia (increased hair thinning or diffuse hair loss), or other symptoms. Approximately three-quarters of women with PCOS (by the diagnostic criteria of NIH/NICHD 1990) have evidence of hyperandrogenemia.
If the patient does not present with ovulatory cycles at three months after ovarian drilling, then the procedure should be combined with CC treatment. The use of gonadotropins should be considered after 6 months of anovulatory cycles following the ovarian drilling procedure. Ovarian drilling should not be indicated as a treatment for menstrual irregularity, metabolic complications or hyperandrogenism in PCOS 29.
She is mentally ill and on tons of drugs all day long? Focusing on something shallow is doable in that kind of state. Plus she gets asspats for being cyberbullied by a mean forum lol. If she genuinely confronted the fact that she completely and utterly fucked up her life, that everything is her fault and she really just sucks as a person inside and out, she'd probably have a massive breakdown. She just numbs all of these feelings with drugs.
Mandy Bush - I've been active with this program for approximate 3 years. I went off the supplements a month ago because I felt I needed a break. My face started breaking out again and my mood swings went haywire. Needless to say, I am back on the program. I am grateful and happy that I have the supplements and all the great resources that Insulite Health has to offer available to me! Check it out, try it, ask questions - the staff is amazing!
Side effects: This herb is safe for short term use and can cause digestive issues or possible a rash when in contact with the skin. You should not take this herb if you have any type of bleeding disorder because it might slow the process of blood clotting. Peony is also not recommended for women who are pregnant because it might cause uterine contractions.
It's good to know I'm not alone with having pcos. I found out when I was 18 years old. When I was gr...owing up and in puberty I never had my period. I remember girls around me complaining about there's in high school. But mine never came. I went to a obgyn when I was 16 she gave me meds to get it started, it only worked when I took the med every 3 months. They also did an ultrasound and found multiple cysts on my ovaries, but she did not know what it was. So I never went back to that doctor she was not very bright. But when I was 18 I was reading a magazine about a girl that has pcos and the symptoms and everything, and it sounded like me. So i went to My mom's obgyn and talked to him about what I read and my history of not getting my period on my own, he did an exam, ran some blood tests, and did other ultrasound. Come to find out I have pcos and was put on birth control and metformin. Which I'm still taking and it's been 11 years since I found out I have pcos. See More
Obesity is associated with PCOS. Obesity not only compounds the problem of insulin resistance and type 2 diabetes (see below), but also imparts cardiovascular risks. PCOS and obesity are associated with a higher risk of developing metabolic syndrome , a group of symptoms, including high blood pressure, that increase the chances of developing cardiovascular disease. It has also been shown that levels of C-reactive protein (CRP), a biochemical marker that can predict the risk of developing cardiovascular disease, are elevated in women with PCOS. Reducing the medical risks from PCOS-associated obesity is important.
Jump up ^ Legro, Richard S.; Arslanian, Silva A.; Ehrmann, David A.; Hoeger, Kathleen M.; Murad, M. Hassan; Pasquali, Renato; Welt, Corrine K.; Endocrine Society (December 2013). "Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline". The Journal of Clinical Endocrinology and Metabolism. 98 (12): 4565–4592. doi:10.1210/jc.2013-2350. ISSN 1945-7197. PMC 5399492. PMID 24151290.
Side effects: Some people who are allergic to ragweed and other plants in the same family are also allergic to milk thistle so taking this herb might cause an allergic reaction. Occasionally people taking milk thistle will complain of gastrointestinal issues but this is rare. I t may also lower blood sugar levels so if you have hypoglycemia or diabetes you might want to try another herbal .
In anovulatory women with PCOS defined according to the Rotterdam consensus (includes all phenotypes except the one defined by the association of hyperandrogenism with ultrasound (US) findings), CC treatment is the first choice for ovulation induction 9,15. This drug is an estrogen receptor modulator (it can act as an estrogen agonist or antagonist) and its mechanism of action is controversial but can be explained as follows. In physiological menstrual cycles, low levels of estrogen promote negative feedback in the hypothalamus and pituitary gland and inhibit the endogenous secretion of gonadotropin during the early follicular phase. When CC is administered in this phase of the cycle, it competes with estrogen for its receptors in the hypothalamus and pituitary, which will block the negative feedback mechanism. Consequently, increased levels of endogenous gonadotropins are released and the dominant follicle is recruited (follicle that has the highest number of follicle-stimulating hormone (FSH) receptors) between the sixth and ninth day of the menstrual cycle 16.
Other pharmacological treatments have attempted to lower IR. Vitamin D has been shown to decrease HOMA-IR despite a lack of change in hyperandrogenism in young, obese PCOS women. Animal studies have demonstrated that treatment with glycyrrhizic acid affecting lipoprotein lipase activity decreases serum insulin and HOMA-IR. Although oral contraceptive pills positively affect hyperandrogenism, they have little to no effect on glucose metabolism by OGTT. Long term oral contraceptive pill use may have some limited benefit in IR but data are limited. A 6 mo course of oral contraceptive pill treatment in adolescent obese PCOS women has demonstrated some improvement in IR.
Where US is available, CC treatment should be initiated between the third and fifth day of the menstrual cycle and the couple should abstain from intercourse (this is not a mandatory measure) until the tenth day of the cycle (when the presence of dominant follicles with a mean diameter of 10 mm or more is assessed via US). Sexual activity is allowed if the patient presents with monofollicular or bifollicular development. The goal of sexual abstinence until the tenth day of the cycle is to minimize the risk for multiple gestations.
I don't want to be a cow thank you. No, I'm not naturally ginger. My friend was on my account last night taking the piss. I've deleted the comments because I'm not a cunt who comments horrible things on people's profiles. We was talking about Luna because I found this thread. I don't even know what the comments meant myself, I was confused. So yeah, say what youse like I'm not really arsed.
A stroll around the block with your dog (spouse/significant other, neighbor, or exercise buddy), your favorite exercise class at the gym, following a video at home, or peddling on an exercise bike while you watch TV…whatever you choose to get you moving will be good.14 Aim to fit in at least 30 minutes, five times a week – the basic recommendations from the US Centers for Disease Control and Prevention.15
Women with PCOS have been shown to have higher levels of advanced glycation end products (AGEs) in their blood. AGEs are compounds formed when glucose binds with proteins, and are believed to contribute to certain degenerative diseases and aging. One small study found that cutting down on dietary AGEs significantly reduced insulin levels in women with PCOS. Foods high in AGEs include animal-derived foods and processed foods. Applying high heat (grilling, searing, roasting) increases levels.
Angela Grassi, a registered dietitian who also has PCOS, says that because women who are overweight are likely to experience more insulin resistance than those who are not, they can get locked into a cycle of weight gain. “The more weight you gain, the more corresponding insulin your body produces, and the more you continue to gain weight,” she said.
Hi dok..may tanung lang po ako..kasi po almost 9 months napo akung d nireregla..dati po kasi nagpatingin nku sa ob gyne at niresetahan ako ng contraceptive pills ung diane 35. Siguro po 3 months din ako uminom nun..at niregla din nman po ako…tinigil ko lang po kasi un kasi po sabi ng matatanda bat daw po ako umiinom ng pills eh wala pa daw po akung anak at asawa bka daw po mas lalong masira matress ko..ano po ba dapat kung gawin .takot kuna po kasing magpatingin sa doktor ulit…sana rwplayan nyo po ako.tnx pi
On rare instances, if I'm in a dire hurry (of the 'ward rounds start in five minutes, I haven't had a single bite to eat since yesterday 1600 and my blood sugar is tanking like Luna's mu opioid receptors' kind), and the person in front of me is taking utter eternities to count out $3.50 for a shitty sandwich or whatever the fuck they bought, I sometimes just pay for my shit and theirs so that I can go to work and listen to the Munchie crop of the day. So I've known a few people who try to game people in a hurry by doing this counting out cash trick on them. At the same time I have been pretty dubious of Luna's stories and I think that almost all the time, it's a cover for stealing.
A case control study examining 100 infertile women with PCOS found that those who supplemented a daily 1500 mg dose of metformin, a medication commonly used to treat PCOS symptoms, with calcium and vitamin D saw improvements in BMI, menstrual abnormalities, and other symptoms. The women in the study added 1,000 mg of calcium a day and 100,000 IU of vitamin D a month to their daily metformin dose for six months.
MRI (or magnetic resonance imaging) scan is a radiology technique which uses magnetism, radio waves, and a computer to produce images of body structures. MRI scanning is painless and does not involve X-ray radiation. Patients with heart pacemakers, metal implants, or metal chips or clips in or around the eyes cannot be scanned with MRI because of the effect of the magnet.
Pre-clinical and clinical evidence was found for Vitex agnus-castus for lowered prolactin, improved menstrual regularity and treatment of infertility. Vitex agnus-castus contains a variety of compounds which bind to dopamine type 2 (DA-2) receptors in the brain; reduce cyclic adenosine mono phosphate (cAMP) and lowered prolactin secretion (Table 1). This was demonstrated in studies using recombinant DA-2 receptor proteins, and basal and stimulated rat pituitary cell cultures [38–41]. Prolactin lowering effects were found in normal and ovariectomised rats . Additional agonistic opiate effects were observed in studies using human opiate receptors cell cultures .
Jump up ^ Pundir, J; Psaroudakis, D; Savnur, P; Bhide, P; Sabatini, L; Teede, H; Coomarasamy, A; Thangaratinam, S (24 May 2017). "Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials". BJOG : An International Journal of Obstetrics and Gynaecology. 125 (3): 299–308. doi:10.1111/1471-0528.14754. PMID 28544572.
Shahin et al.  Randomised controlled trial using with an active control arm for comparative effectiveness. One menstrual cycle. 147 women aged less than 35 years with un-explained infertility and recurrent clomiphene resistance for ovulation induction. Anovulatory participants were excluded (n = 28). Anovulation was diagnosed by serum oestradiol < 200 ng/ml and absence of a dominant ovarian follicle on day 9 of the menstrual cycle. Complete data sets available for 119 women. All women received Clomiphene citrate (clomiphene) 150 mg on menstrual cycle days 3–7. A randomised group also took Cimicifuga racemosa 20 mg per day between days 1–12. Cimicifuga racemosa described as ‘phytoestrogens’ was provided in the commercial preparation Klimadynon®, manufactured by Norica in Germany. A trigger injection (human chorionic gonadotropin, 10 000 IU) and timed intercourse was recommended when a dominant follicle > 17 mm was observed. Pregnancy rate measured as increasing serum human chorionic gonadotropin (HCG) over two days. Clinical pregnancy defined as detection of gestational sac with embryonic heart-beat. Endometrial thickness measured by ultrasound concurrent with follicle maturation monitoring. Number of days to ovulation (trigger injection) Serum concentration for FSH oestradiol and LH. Luteal progesterone measured on days 21–23 of the menstrual cycle. Miscarriage and multiple pregnancy rates. Pregnancy rate in clomiphene alone group was 20.3% and 43.3% in the clomiphene plus Cimicifuga racemosa group (P < 0.01). Clinical pregnancy rate in the combination group was 36.7% versus 13.6% in the clomiphene alone group (P < 0.01). Endometrial thickness in combination group was 8.9 (±1.4) versus 7.5 (±1.3) (p < 0.001). Days to ovulation in clomiphene alone group was 13.0 ± 1.1 and in the clomiphene plus Cimicifuga racemosa group 14.2 ± 1.3 (n.s.). Luteal progesterone peak (ng/ml) in combination group was 13.3 (±3.1) versus 9.3 (±2.0) in clomiphene alone group (p < 0.01). All other hormone measures were not significantly different No detailed current baseline criteria for other causes of infertility. Confounding factors include current male fertility status. This may have caused an imbalance between the two groups. There is no description of the distribution of excluded (anovulatory) participants between groups.
meh. I think she takes selfies (including the body posi ones) because it helps her cultivate her image rather than because she thinks she's gorgeous. She's not like many of the other cows in that she doesn't try to hide her cellulite or mismatching eye sockets or her flab. Her imperfections feed into her junkie chic look, which is why calling them out every time she posts a picture ad nauseum doesn't make sense. She knows she has these features and doesn't seem to care, she mentions them herself, and she might even like how they fit into her style. She's totally comfortable with them and places a much higher importance on aesthetic than having a beautiful body.