Our second search for clinical trials was performed without language restriction and included randomised controlled trials, non-randomised, open label and single arm clinical trials. We included clinical studies investigating commercially available herbal extracts and investigations that compared the effectiveness of herbal medicine with pharmaceuticals. We excluded clinical studies investigating herbal medicines with unrelated outcomes (including pre-menstrual syndrome, endometriosis and mastalgia) and clinical studies examining the effectiveness of complex herbal formulas for PCOS and associated oligo/amenorrhoea and hyperandrogenism, without demonstration of a mechanism of effect for the whole complex formula. We compared data from laboratory and animal studies with the outcomes of clinical trials. Clinical studies were assessed for risks of bias at study and outcome levels with risks summarised, tabulated (Tables 1 and ​and2)2) and presented in contextual narrative.


Otros síntomas del PCOS son provocados por problemas con la insulina, otra hormona del cuerpo. La insulina ayuda a que el azúcar (también llamada glucosa) pase del torrente sanguíneo a las células para que la utilicen como energía. Cuando las células no responden normalmente a la insulina, aumenta el nivel de azúcar en la sangre. Además, el nivel de insulina sube a medida que el cuerpo produce más y más para tratar de que la glucosa llegue a las células. Demasiada insulina aumenta la producción de andrógenos,5 que luego causan los síntomas del PCOS. Los niveles altos de insulina también pueden aumentar el apetito y provocar un aumento de peso.3 Los niveles de insulina altos también se relacionan con la enfermedad llamada acantosis nigricans.3
The diagnostic workup should begin with a thorough history and physical examination. Clinicians should focus on the patient's menstrual history, any fluctuations in the patient's weight and their impact on PCOS symptoms, and cutaneous findings (e.g., terminal hair, acne, alopecia, acanthosis nigricans, skin tags).19 Patients should also be asked about factors related to common comorbidities of PCOS.
Mammalian ovary development undergoes important changes during the perinatal period, moment when follicles are assembled and start to develop in a process not well known, involving endocrine and paracrine factors. In order to investigate the effect of two different hormonal environments on the early development of the ovary, we used an autologous transplant model in which Syrian hamster fetal ovaries were grafted under the kidney capsule of males hosts previously unilaterally or bilaterally orchidectomized. After 35 days of graft, ovaries and kidney parenchyme of the host male did not present signs of rejection. Ovaries contained primordial, primary follicles, secondary follicles and few tertiary follicles with morphological features similar to ovaries of control females of 35 days of age. Healthy primary and secondary follicles of experimental groups had frequency distribution and size similar to control ovaries but tertiary follicles were scarce in control as well as in grafts where they were mainly atretic. PCNA, marker of proliferation, was immuno detected in granulosa cells of growing follicles and the marker of apoptosis, Caspase 3 active, was evident mainly in secondary follicles. Immunoreactivity for steroidogenic proteins, StAR, 3-βHSD and aromatase detected in the follicular wall cells and the decreased serum levels of FSH without important changes in testosterone in bilateral orchidectomized males that received ovarian graft, and testosterone decreased without changes in FSH levels in unilateral orchidectomized males (UO) with ovarian graft, all together suggest the effect of steroid hormones produced by the ovary. In conclusion, the experimental model of autologous transplant presents evidence of early ovary development under the kidney capsule and its functional integration to the endocrine axis of the host male.
I don't mean to break any hearts, but if something happens to Lurch, the chances of Tuna fixing herself are still near zero. She's addicted to the life, they fight plenty and she has made mention before of hooking customers up, etc. It's very rare for a junkie couple to have one person lifting all the weight. On the off chance he does go away, she'll latch on to someone else and get back into the same role (holding / palming / whatever)

El SOP es la causa más común de infertilidad en la mujer y afecta del 6 al 12 % (hasta 5 millones) de mujeres en edad reproductiva en los Estados Unidos. Pero es mucho más que eso. Las mujeres con este síndrome con frecuencia tienen resistencia a la insulina (información disponible solo en inglés), es decir que no responden eficazmente a la insulina, por lo que sus cuerpos continúan produciendo más. Se piensa que el exceso de insulina hace aumentar los niveles de andrógenos (hormonas masculinas que también tienen las mujeres) producidos por los ovarios (órganos que producen los óvulos), lo cual puede hacer que no se liberen los óvulos (ovulación) y puede causar menstruaciones irregulares, acné, debilitamiento del cabello y crecimiento excesivo de vello en la cara y el cuerpo.

Some people don't gain weight. It's not the antipsychotic that make you gain weight per se anyway (it does kinda fuck up metabolism thp) but the munchies you get from it. I don't see Luna being able to handle them enough to stay at normal weight if she had it, she's always snacking on shit, it would only be worse with the quietapine generated ravenous hunger.
With all of these options, it can’t be stressed enough that a woman will be making a choice about what’s most important to her in the moment. If a woman wants to get pregnant, she can’t also treat male hormone problems (excess hair growth, male-pattern hair loss, acne) simultaneously — those are two conflicting goals. But there’s a bright spot: Once she does get pregnant, the high levels of estrogen in her system help suppress hair growth, notes Dunaif.
PCOS es un complemento que ayuda a equilibrar los niveles hormonales (exceso de testosterona) en las mujeres con SOP. Esos desequilibrios hormonales provocan en la mayoría de los casos signos externos de hiperandrogenismo como exceso de vello, caída excesiva del cabello y acné. Al regular tus niveles hormonales, conseguirás suavizar y mejorar esos signos externos 🙂
Two important things to note are that the long term safety effects of use are not known (but the drug has been in use for decades already) and spironolactone IS NOT SAFE in pregnancy, so it is commonly used in conjunction with birth control pills. This use of birth control pills also protects against abnormal growth of the lining of the uterus. Some women cannot take birth control pills, in which case it is important to use other means of birth control if you are sexually active while taking spironolactone.
Vitamin D deficiency may play some role in the development of the metabolic syndrome, so treatment of any such deficiency is indicated.[74][75] However, a systematic review of 2015 found no evidence that vitamin D supplementation reduced or mitigated metabolic and hormonal dysregulations in PCOS.[76] As of 2012, interventions using dietary supplements to correct metabolic deficiencies in people with PCOS had been tested in small, uncontrolled and nonrandomized clinical trials; the resulting data is insufficient to recommend their use.[77]
Your health care provider will ask you a lot of questions about your menstrual cycle and your general health, and then do a complete physical examination. You will most likely need to have a blood test to check your hormone levels, blood sugar, and lipids (including cholesterol). Your health care provider may also want you to have an ultrasound test. This is a test that uses sound waves to make a picture of your reproductive organs (ovaries and uterus) and bladder (where your urine is stored). In girls with PCOS, the ovaries may be slightly larger (often >10cc in volume) and have multiple tiny cysts.
I've noticed a repeating pattern with cows where someone makes an off hand comment about their appearance, which was probably more of a: "wow that looks fucking bizarre but I don't want to be flat out rude but am so baffled I still have to comment" comment. Which I assume is what happened with the angel shit. If anyone actually said that. She just misinterpreted it as a compliment.
PCOS stands for polycystic ovary syndrome. The exact cause of PCOS is unknown. What is known is that PCOS has to do with hormone imbalances. With PCOS, your body may have high amounts of two hormones: androgen and insulin. These hormonal issues can cause changes in your body’s ability to release an egg (ovulate) and can lead to irregular periods, ovarian cysts, trouble getting pregnant, and other symptoms.
Although aromatase inhibitors have been used in women with PCOS as an alternative method to avoid the anti-estrogenic effect of CC on the endometrium, these compounds are not typically used in clinical practice to treat infertility in these patients. Their mechanism of action is based on reducing the peripheral conversion of androgens to estrogens in ovarian granulosa cells by blocking aromatase. Consequently, a decrease in estrogen serum levels and in its negative feedback in the hypothalamus and pituitary gland is noted, resulting in increased endogenous gonadotropin release 41.
The study evaluated psychological symptoms in 126 women diagnosed with PCOS. Participants completed surveys using a standard tool for evaluating mental health, the Brief Symptom Inventory (BSI), and their responses were compared with those of adult women in the general population and of adult women undergoing outpatient psychiatric care. While small, and not a randomized controlled trial, the study offers insight into the psychiatric manifestations of different PCOS symptoms, Reame says. Body hair and menstrual problems most strongly predicted anxiety, while obesity was most strongly associated with hostility, the study found.
i wonder if luna's dad knows about how much she complains about him. all he would have to do is google her name to see how much she hates him. if i were her dad and i saw the shit she says about me, i'd kick her to the curb. poor dude is letting her have what she wants, when she wants it, and she STILL talks about him like he's a monster. maybe he's a piece of shit but damn, at least he's trying. what an ungrateful brat
Various laparoscopic methods, including electrocautery, laser drilling, and multiple biopsy, have been used with the goal of creating focal areas of damage in the ovarian cortex and stroma. According to the Society of Obstetricians and Gynaecologists of Canada (SOGC), laparoscopic ovarian drilling may be considered in women with clomiphene-resistant PCOS, especially in the presence of other laparoscopic indications. [2] A small French study also suggested that surgical management via ovarian drilling with hydrolaparoscopy may be beneficial in cases of PCOS that are resistant to clomiphene citrate. [87]
Si bien no se recomienda como primer tratamiento, existe una operación para el tratamiento de PCOS, llamada incisión ovárica. Se realiza un pequeño corte encima o debajo del ombligo y se inserta un pequeño instrumento llamado laparoscopio que sirve como telescopio en el abdomen. Durante la laparoscopía, el médico puede hacer punciones en el ovario con una aguja delgada que tiene corriente eléctrica para destruir una pequeña porción del ovario. La cirugía puede mejorar los niveles hormonales y la ovulación, aunque es posible que la mejoría dure solo unos meses.
This can be a key element for dynamic health for women with polycystic ovarian syndrome and must be considered a regular a part of your routine. Exercise can definitely boost the body’s sensitivity to sugar and address insulin resistance. It is also a great way to feel good and maybe learn a new skill. There are so many types of exercise you should be able to find something that appeals to you and is appropriate for your fitness level. Some fun exercise choices could include walking, housework, gardening, biking, running, swimming, yoga, and weight lifting as well as sports like soccer, squash, softball, tennis, skiing or even salsa dancing.
Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects about 5 to 10 percent of women during their childbearing years. Typically, the ovaries contain multiple small cysts, which are often slightly enlarged. About 1 in 5 women have polycystic ovaries appearing on ultrasound scans but do not have the other features of this syndrome. These cysts do not require surgical removal. Polycystic ovaries make more male hormones (androgens) than do normal ovaries. The exact cause for PCOS is not known, but sometimes it is hereditary.
There are also experts who suggest taking more of a lifestyle treatment approach rather than medication, which some call a “Band-Aid” to symptoms. One such expert is Amy Medling, a certified health coach who is founder of PCOS Diva and author of Healing PCOS: A 21-Day Plan for Reclaiming Your Health and Life with Polycystic Ovary Syndrome. She stresses that some women don’t feel well on some of these drugs (she was one of them), so looking at other ways to manage PCOS will get them to a more balanced place. “I hear from many women who are frustrated and hopeless and feel underserved by the mainstream way of managing PCOS,” says Medling.
she doesnt say shit until someone else brings her up, she screencaps probably most of the milk for this thread and yeah has left her icon in a few times and pretends to be nice to tuna for milk, but any of you bitches would do the same if tuna talked to you and you were screencapping as many posts as she does. just stfu already, theres no milk besides the stuff from tuna that shes farming for us
Women with PCOS have been shown to have higher levels of advanced glycation end products (AGEs) in their blood. AGEs are compounds formed when glucose binds with proteins, and are believed to contribute to certain degenerative diseases and aging. One small study found that cutting down on dietary AGEs significantly reduced insulin levels in women with PCOS. Foods high in AGEs include animal-derived foods and processed foods. Applying high heat (grilling, searing, roasting) increases levels.
When a woman isn’t ovulating regularly, the lining of her uterus (the endometrium) isn’t being exposed to the normal patterns of estrogen and progesterone. With no progesterone exposure, the lining won’t shed completely (when it sheds, that’s what women see as their period). “If this goes on, a woman can develop endometrial hyperplasia and even endometrial cancer,” she adds. (Endometrial hyperplasia is when the lining of the uterus is abnormally thick, most likely due to estrogen without progesterone exposure, and it can lead to uterine cancer.) (3)
There are also experts who suggest taking more of a lifestyle treatment approach rather than medication, which some call a “Band-Aid” to symptoms. One such expert is Amy Medling, a certified health coach who is founder of PCOS Diva and author of Healing PCOS: A 21-Day Plan for Reclaiming Your Health and Life with Polycystic Ovary Syndrome. She stresses that some women don’t feel well on some of these drugs (she was one of them), so looking at other ways to manage PCOS will get them to a more balanced place. “I hear from many women who are frustrated and hopeless and feel underserved by the mainstream way of managing PCOS,” says Medling.

The paper is titled: “Differential Contributions of Polycystic Ovary Syndrome (PCOS) Manifestations to Psychological Symptoms”; it was published online in January 2014. The other authors are: Beth Bailey, PhD; Stacey Williams, PhD; and Sheeba Anand, MD (all from East Tennessee State University). The research was partially funded by the NIH Contraception and Infertility Loan Repayment Program. The authors declare no financial or other conflicts of interest.
PCOS is a life-long condition and although the exact cause is yet to be identified, it is believed to have epigenetic origins, influenced by the uterine environment and behavioural factors [19]. Being overweight exacerbates all aspects of PCOS due to underlying metabolic disturbances [3]. Signs and symptoms are mediated by hormonal disorder including elevated androgens and fasting insulin, and abnormal relative ratio of the gonadotropins luteinising hormone (LH) and follicle stimulating hormone (FSH) [19]. Endocrine imbalances occur within the framework of disordered ovarian folliculogenesis, chronic anovulation, clinical signs of hyperandrogenism and metabolic syndrome [19].
Dr. Victor Luna completed his medical education at Escuela Autonoma de Ciencias Medicas de Centroamerica in San Jose, Costa Rica. He then participated in an internship at LSU Health Science Center where he later completed his residency in Internal Medicine where he served as the chief resident for his final year. Dr. Luna continued his education by completing a fellowship at University of South Florida.
A stroll around the block with your dog (spouse/significant other, neighbor, or exercise buddy), your favorite exercise class at the gym, following a video at home, or peddling on an exercise bike while you watch TV…whatever you choose to get you moving will be good.14 Aim to fit in at least 30 minutes, five times a week – the basic recommendations from the US Centers for Disease Control and Prevention.15
This therapeutic modality is also considered a second-line treatment for the infertility of women with PCOS. However, because it is an invasive method that requires general anesthesia and has a higher cost and potential complications, this technique should be used in cases of anovulatory women with CC-resistant PCOS who require laparoscopy for another reason (pelvic pain, adnexal mass, etc.). This technique can be performed using monopolar electrocautery or laser techniques, with both exhibiting a similar efficacy and the goal is between 4 and 10 punctures because a larger number may favor the development of premature ovarian failure 25,29. The mechanism of action of ovarian drilling in the treatment of infertility in women with PCOS is suggested to be based on the decreased secretion of androgens and consequent reduction of peripheral aromatization of these compounds into estrone. Furthermore, the follicular microenvironment becomes more estrogenic, which facilitates follicular growth 30. Regarding the efficacy of ovarian drilling, observational studies demonstrated that the ovulation rate was between 54 and 76% in the 6 months after the procedure and 33 and 88% in the 12 months after the procedure. During these periods, the spontaneous pregnancy rate ranged between 28 and 56% and 54 and 70%, respectively 31.

PCOS is associated with multiple metabolic defects, including metabolic syndrome. Twice as many women with PCOS have metabolic syndrome as in the general population, and about one-half of women with PCOS are obese.1,9 The presence of PCOS is also associated with a fourfold increase in the risk of type 2 diabetes mellitus.10 There is an increased prevalence of nonalcoholic fatty liver disease,11,12 sleep apnea,13 and dyslipidemia14 in patients with PCOS, even when controlled for body mass index. Rates of cardiovascular disease are higher in patients with PCOS, but increased cardiovascular mortality has not been consistently demonstrated.15,16 Finally, there is evidence to suggest an increased risk of mood disorders among patients with PCOS.17,18
Saw Palmetto (Serenoa repens, Sabal serrulata) This herb has anti estrogenic effects and also has been found to decrease the testosterone levels in the blood. Both effects are very positive for women with PCOS .9 The herb has properties that can block the process of testosterone turning into DHT (dihydrotestosterone, a by-product of testosterone) which in turn lowers male hormones in the body.
Bragging moment! For the first time in 13 YEARS I'm having a normal period! Bleeding normally, NOT having excruciating cramps, NOT breaking out terribly and my hair is NOT falling out! I am so happy I could cry! The Insulite sytem helped me stay sane and given me my sanity back. I am in control of my body for the first time in my entire life. Truly a blessing.

This work attempts to give a review of ovarian innervation, the mechanism of regulation of nerve activity and the role of the sympathetic activity in ovarian pathologies affecting reproductive function. We provide a succinct outline of the findings of our group in this area. The participation of stress as an etiological factor for ovarian pathologies throughout animal models and preliminary data in patients with polycystic ovary syndrome give strong support for a participation of sympathetic nerves in the ovary function both in normal and pathological states.


A team approach involving care by primary care and subspecialist physicians can be helpful to address the multiple manifestations of the syndrome. Goals for treatment (e.g., treating infertility; regulating menses for endometrial protection; controlling hyperandrogenic features, including hirsutism and acne) must account for the patient's preferences because therapy selection may otherwise conflict with outcomes that the patient considers important. Metabolic complications should be addressed in every patient via a blood pressure evaluation, a lipid panel, and a two-hour oral glucose tolerance test. Patients who are overweight should be evaluated for signs and symptoms of obstructive sleep apnea. All patients should be screened for depression (Figure 119).
Polycystic Ovarian Syndrome is a condition that affects a woman's hormonal levels. Women with PCOS produce higher than normal male hormones which cause them to skip their monthly periods and make it harder for them to get pregnant. PCOS also causes hair growth on the face and body, and baldness. So basically, women with PCOS have dense hair growth on those areas of their bodies where they're not supposed to have excess hair. But they start losing hair from their scalps, leading to baldness. PCOS can contribute to long-term health problems like diabetes and heart disorders.

Clinically speaking, the hyperandrogenism seen in PCOS is associated with hirsutism more than acne or alopecia and therefore hirsutism is an impetus for young women seeking care[2]. Many PCOS women are also overweight (BMI > 25kg/m2) or obese (BMI > 30kg/m2), although adiposity is not a defining criteria for PCOS. Obesity is highly prevalent in the general population and in PCOS women and is an independent risk factor for CAD[3]. Obesity in adolescents is correlated with insulin resistance (IR) and dyslipidemia[4]. PCOS related ovulatory dysfunction in adolescents often correlates to adolescent obesity[5]. Genetic predisposition to PCOS has been suspected for many years[6] and data link obesity and metabolic disturbances in PCOS with genetic polymorphisms[7,8]. Even male first degree relatives of women with PCOS have a higher incidence of metabolic syndrome (MS), the closest corollary to PCOS in men[9].
Christina Holaday - I am so excited about the changes I have already had. I started taking the Insulite supplements as soon as they arrived. The first couple days I didn't notice much but the next day I had an abundance of energy. I wanted to do everything and had energy to do it. I love how I feel right now and will continue to focus on making the necessary diet and movement changes slowly. This Insulite System has given me my hope back. I feel happy and motivated which I haven't felt in months. I hope this can encourage others because I was at the end of my rope. Thanks for listening”
When a woman isn’t ovulating regularly, the lining of her uterus (the endometrium) isn’t being exposed to the normal patterns of estrogen and progesterone. With no progesterone exposure, the lining won’t shed completely (when it sheds, that’s what women see as their period). “If this goes on, a woman can develop endometrial hyperplasia and even endometrial cancer,” she adds. (Endometrial hyperplasia is when the lining of the uterus is abnormally thick, most likely due to estrogen without progesterone exposure, and it can lead to uterine cancer.) (3)
she's mentioned before that "healthy foods" are "rich people foods" which is just total bullshit to anyone who's gone grocery shopping. she used to post cvs hauls of frozen pizzas and candy she'd get for herself and lurch and it would be one nights worth of food. cvs is overpriced as fuck but even at a normal store, buying exclusively prepackaged junk food is expensive as fuuuccck. buy some rice and beans.
About Blog Furocyst is an innovative product (extracted and developed through a novel & innovative U.S. patented process) involving separations of active ingredients from the natural plant without affecting chemical properties of the active fractions. No chemicals are used. It is a natural and promising dietary supplement for the management of Polycystic Ovary Syndrome (PCOS).
Aunque el síndrome de ovario poliquístico (que antes se llamaba "síndrome de Stein-Leventhal") se identificó por primera vez en la década de los años treinta del siglo XX, los médicos todavía no conocen sus causas con certeza. Las investigaciones sugieren que puede estar relacionado con un aumento de la fabricación de insulina en el cuerpo. Las mujeres con síndrome de ovario poliquístico es posible que produzcan demasiada insulina, lo que estimula a sus ovarios a liberar un exceso de hormonas masculinas. El síndrome de ovario poliquístico parece darse por familias, de modo que si lo padece alguna pariente tuya, tú podrías ser proclive a desarrollarlo.
A veces los síntomas del SOP son claros, a veces son menos obvios. Quizás visite a un dermatólogo (médico de la piel) por acné o crecimiento del vello, a un ginecólogo (médico que trata las afecciones médicas de las mujeres y de los órganos reproductivos femeninos) por periodos mensuales irregulares y a su médico de familia por aumento de peso, sin darse cuenta de que todos los síntomas son parte del SOP. Algunas mujeres con SOP tendrán solo un síntoma; otras los tendrán todos. Las mujeres de todas las razas y grupos étnicos pueden presentar SOP.
If you’ve been told you have PCOS, you may feel frustrated or sad. You may also feel relieved that at last there is a reason and treatment for the problems you have been having, especially if you have had a hard time keeping a healthy weight, or you have excess body hair, acne, or irregular periods. Having a diagnosis without an easy cure can be difficult. However, it’s important for girls with PCOS to know they are not alone. Finding a health care provider who knows a lot about PCOS and is someone you feel comfortable talking to is very important. Keeping a positive attitude and working on a healthy lifestyle even when results seem to take a long time is very important, too! Many girls with PCOS tell us that talking with a counselor about their concerns can be very helpful. Other girls recommend online chats. The Center for Young Women’s Health offers a free and confidential monthly online chat for girls and young women with PCOS.
Sin tratamiento, el endometrio que se vuelve cada vez más grueso puede pasar a ser cáncer endometrial. PCOS también está relacionado con otras enfermedades que se presentan después de algunos años, como resistencia a la insulina, diabetes tipo 2, colesterol alto, endurecimiento de las arterias (aterosclerosis), presión alta y enfermedades del corazón.
Jump up ^ Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA (2014). "The physiology and clinical utility of anti-Mullerian hormone in women". Human Reproduction Update (Review). 20 (3): 370–85. doi:10.1093/humupd/dmt062. PMID 24430863.
×