This is an important distinction; given her longtime love for drugs, tendency to abuse everything she gets, and unwillingness to go sober even when she's not on H, there's a good chance that Luna has 'polysubstance dependence' and is chasing the feeling of being 'not sober' by abusing her meds. The drugs she abuses don't have to get her high if that is the case, just do enough to make her feel a change in her consciousness (e.g. sedation, calm). It's common in people with untreated mental illness. Luna probably hates herself so much that she just can't handle being left alone with her sober self.
The definitive cause of PCOS is unknown, but researchers have found a strong link to insulin resistance, a genetic condition often associated with diabetes, in which the muscle, fat, and liver cells do not respond properly to insulin and thus cannot easily absorb glucose (sugar) from the bloodstream. As a result, the body produces higher and higher levels of insulin to help glucose enter the cells.
she's only playing dress up as a heroin addict because she knows she always has a safety net. those are the kids that go the hardest, the ones that are so privileged they think nothing really bad is ever going to happen to them. but she's already ruined her appearance and job opportunities, so i don't know where this weird superiority complex for being "poor" comes from? even if her daddy does save her she can't just get a top notch face lift like courtney love. no one cares. she's already so fucked and doesn't know it.
This review includes 18 preclinical laboratory based studies and 15 clinical trials. We found reproductive endocrine effects in oligo/amenorrhoea, hyperandrogenism and/or PCOS for six herbal medicines. The quality of evidence, as determined by the volume of pre-clinical studies and the methodological quality of clinical trials, was highest for the herbal medicines Vitex agnus-castus, Cimicifuga racemosa and Cinnamomum cassia, for which there were laboratory and/or animal studies demonstrating endocrine mechanisms of action consistent with clinical outcomes shown in RCT’s with low risks for bias. However, replicated RCT data was only found for one herbal medicine, Cimicifuga racemosa.
Randomisation for 206 women 12 were excluded due to failure to respond (treatment group n = 7, control n = 5). 2. Endometrial thickness monitored by ultrasound. Endometrial thickness in the clomiphene alone group was 8.5 mm (±1.9) compared to 12.9 (±2.3) in the clomiphene plus Cimicifuga racemosa group (p < 0.001). The miscarriage rate per pregnancy for the clomiphene alone group was 5 out of 33 (15.2%) and 6 out of 71 (8.5%) in the clomiphene plus Cimicifuga racemosa group.
Palm jaggery o palm asukal ay itinuturing na isang malusog na pagpipilian kaysa sa regular na puting asukal dahil sa pagmamay-ari nito upang kontrolin insulin at asukal sa dugo antas. Ito rin ay nagtataglay ng isang mababang glycemic index at magpapalaki enerhiya na antas. Ang mas mataas na mga antas ng insulin ay karaniwan sa mga PCOS pasyente, at ito hindi nilinis uri ng jaggery (o asukal) ay maaaring makabuluhang epekto sa iyong kalusugan kapag isinama sa iyong diyeta.
PCOS is genetic and presents differently in each woman of childbearing age. For some women, symptoms emerge shortly after they begin menstruating. Others may not show signs of the disorder until later in life, or after substantial weight gain, and many don’t receive a diagnosis until they are struggling to get pregnant. A community-based prevalence study published in 2010 found that approximately 70 percent of the 728 women in the cohort had PCOS, but had no pre-existing diagnosis.  
73. Roy KK, Baruah J, Sharma A, Sharma JB, Kumar S, Kachava G, Karmakar D. A prospective randomized trial comparing the clinical and endocrinological outcome with rosiglitazone versus laparoscopic ovarian drilling in patients with polycystic ovarian disease resistant to ovulation induction with clomiphene citrate. Arch Gynecol Obstet. 2010;281:939–944. [PubMed]
The paper is titled: “Differential Contributions of Polycystic Ovary Syndrome (PCOS) Manifestations to Psychological Symptoms”; it was published online in January 2014. The other authors are: Beth Bailey, PhD; Stacey Williams, PhD; and Sheeba Anand, MD (all from East Tennessee State University). The research was partially funded by the NIH Contraception and Infertility Loan Repayment Program. The authors declare no financial or other conflicts of interest.
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PCOS is the most common cause of anovulatory (pronounced an-OV-yuh-luh-tawr-ee) infertility, meaning that the infertility results from the absence of ovulation, the process that releases a mature egg from the ovary every month. Many women don't find out that they have PCOS until they have trouble getting pregnant...Read more about PCOS NIH - National Institute of Child Health and Human Development


That pic in the last thread with her collarbones made me laugh so much. Bitch has her arms bent at an awkward angle behind her back you can see where the neck squashes awkwardly on her shoulder because of the abnormal way shes twisting and sticking her neck out. Imagine being a fly on the wall at hers (one of the many) and seeing her take a selfie like that kek
The second-line pharmacological treatment of infertility in anovulatory women with PCOS includes the use of gonadotropins [recombinant follicle-stimulating hormone (FSHr) or human menopausal gonadotropin (HMG)] for timed intercourse or intrauterine insemination (IUI) 9. Due to the higher cost of this therapeutic modality, an evaluation of the tubal patency is recommended prior to initiating the ovarian stimulation with gonadotropins if this procedure was not performed prior to initiating CC treatment. If the fallopian tube is opened and the sperm concentration is suitable for in vivo fertilization, the ovarian stimulation begins with low doses of gonadotropins (37.5 to 75 IU/day or every other day) to achieve monofollicular growth and reduce the risk of complications (OHSS and multiple gestation) 25. US monitoring of the follicular growth (follicular diameter measurement) is mandatory in this case and the endogenous secretion of gonadotropins does not need to be inhibited with gonadotropin-releasing hormone analogues (GnRH-a) during the timed intercourse cycles. The administration of hCG (used to simulate the endogenous peak of luteinizing hormone for final oocyte maturation and ovulation triggering) is unnecessary because it does not increase the probability of conception during ovulation induction cycles for timed intercourse 21. It is important to note that if gonadotropin is chosen as the treatment option, the IUI has a higher likelihood of successful pregnancy compared with timed intercourse in patients with subfertility 26.
Diet is crucial component in treating PCOS and really should be considered along with herbal remedies a key consideration when managing this disorder. A well-balanced junk free diet filled with PCOS foods will also help control putting on weight too which could lessen your PCOS symptoms. PCOS food options do not have to exclude all your favorite dishes, you can still enjoy a delectable range of lean proteins, fruit, veggies and whole grain products despite polycystic ovarian syndrome problems. Many women with PCOS think carbohydrates are the enemy; however, high fiber and whole grain carbohydrates have numerous vitamins and nutrition vital so consuming these types of foods also help control glucose and reduce the influence of blood insulin sensitivity. A small decrease in carb intake may be recommended if your polycystic ovarian syndrome is severe but don’t make any major changes before you talk to your physician. Keep in mind you should spread your carb consumption equally across the entire day from breakfast to an evening snack. This helps keep the glucose level even all the way through the night. It’s also wise to combine your carbohydrates with a lean protein source every meal (including snacks) because this will stabilize your blood sugar levels. Desserts, chocolate, sodas as well as an excessive amount of juice are not considered to be PCOS foods and should be avoided because they can negatively impact polycystic ovarian syndrome symptoms and sabotage your efforts to stay healthy.
Metformin has been tested in combination with cholesterol lowering medications. Pretreatment of obese PCOS patients with atorvastatin (20 mg per day for 3 mo) followed by 3 mo of metformin (1500 mg per day) resulted in more effective lowering of HOMA-IR than metformin alone[80]. Other similar data show that combined treatment with metformin and atorvastatin compared to metformin alone produced similar but significant improvements in IR. Combination therapy only showed successful reduction of hyperandrogenism and not IR[81].

Paeonia lactiflora in combination with Glycyrrhiza spp. Aqueous extract Shakuyaku- kanzo-to (TJ-68) One laboratory study examined the effects for the combination Paeonia lactiflora and Glycyrrhiza uralensis on testosterone, oestradiol, FSH and LH in sterilised female rats [53]. Two single arm clinical trials examined androgen concentrations Following treatment with Paeonia lactiflora and Glycyrrhiza uralensis in the Chinese herbal combination Shakuyaku-kanzo-to. One included infertile oligomenorrhoeic women with hyperandrogenism (n = 8) [58] and the other included women with oligo/amenorrhoea and PCOS (n = 34) [59]. 1. Reduced total and free testosterone [53, 58, 59].
The treatment of polycystic ovarian syndrome has evolved considerably since the influence of insulin has been discovered. In the past, treatment was often aimed exclusively at specific symptoms rather than trying to impact some of the underlying influences. Symptoms can definitely be improved individually but addressing influencing conditions like insulin resistance often produces broader results. If insulin resistance is a factor in your PCOS (some women with PCOS are not insulin resistant), then the most effective course of action is to improve your diet. Start a regular exercise program and take supplements or medication recommended by your health care provider.
I found out I had PCOS when i was 19 years old after I had lost a baby at 23 weeks along. I had gott...en my period 2 times a year so every 6 months.. I was told I wouldnt be able to have kids. Welm she had put me on medication for it and I have been on this medication for 2 years and I had lost 150 lbs and then in october of 2012 i found out I was pregnant again.. So I wasnt so thrilled about it because I thought I would lose this one too. Well needlesa to say on July 3, 2013 I had a precious baby boy!! And continue to take my medication:) See More
3. Serum hormones during follicular phase oestradiol, LH and FSH. Luteal progesterone measured day 21–23 of the cycle. Serum LH was 8.0 (±0.9) in the clomiphene group and 5.7 (±0.9) in the clomiphene plus Cimicifuga racemosa group (p < 0.001) and oestradiol was 228.3 (±30.2) in the clomiphene alone group and 299.5 (±38.9) \in the clomiphene plus Cimicifuga racemosa group (p = 0.01)

she's only playing dress up as a heroin addict because she knows she always has a safety net. those are the kids that go the hardest, the ones that are so privileged they think nothing really bad is ever going to happen to them. but she's already ruined her appearance and job opportunities, so i don't know where this weird superiority complex for being "poor" comes from? even if her daddy does save her she can't just get a top notch face lift like courtney love. no one cares. she's already so fucked and doesn't know it.
Second-line therapy, when clomiphene citrate fails to lead to pregnancy, is either exogenous gonadotropins or laparoscopic ovarian surgery. [2, 3] If gonadotropins are used, a low-dose regimen is recommended, [3] and patients must be monitored with ultrasonography and laboratory studies. [2] Note that gonadotropin therapy is expensive and is associated with an increased risk of multiple pregnancy and ovarian hyperstimulation syndrome. [2]

Dok goodevening po may pcos po ako pinainum po ako dati ng ob kp ng metformin at clomid saka folic acid po posible po ba kaya na mabuntia na po akO. At ok lang po ba pasabayin ko ung gamot na po un? 6Months ko na po kaso di nakakausap ob ko kasi po nandito ako sa saudi dinala po ako ng asawa ko dito para po sakali makabuo na kamo salamat po sana po masagot nyo po question ko. Godbless
PCOS is a life-long condition and although the exact cause is yet to be identified, it is believed to have epigenetic origins, influenced by the uterine environment and behavioural factors [19]. Being overweight exacerbates all aspects of PCOS due to underlying metabolic disturbances [3]. Signs and symptoms are mediated by hormonal disorder including elevated androgens and fasting insulin, and abnormal relative ratio of the gonadotropins luteinising hormone (LH) and follicle stimulating hormone (FSH) [19]. Endocrine imbalances occur within the framework of disordered ovarian folliculogenesis, chronic anovulation, clinical signs of hyperandrogenism and metabolic syndrome [19].
Patients with polycystic ovarian syndrome (PCOS) who have impaired glucose tolerance should start a comprehensive program of diet and exercise to reduce their risk of developing diabetes mellitus. Encourage moderate physical activity, provided the patient has no contraindications. Discourage smoking because of the increased risk of cardiovascular disease. In addition, obese women with PCOS can benefit from a low-calorie diet for weight reduction.
A 2017 review concluded that while both myo-inositol and D-chiro-inositols may regulate menstrual cycles and improve ovulation, there is a lack of evidence regarding effects on the probability of pregnancy.[94][95] A 2012 and 2017 review have found myo-inositol supplementation appears to be effective in improving several of the hormonal disturbances of PCOS.[96][97] Myo-inositol reduces the amount of gonadotropins and the length of controlled ovarian hyperstimulation in women undergoing in vitro fertilization.[98]A 2011 review found not enough evidence to conclude any beneficial effect from D-chiro-inositol.[99] There is insufficient evidence to support the use of acupuncture.[100][101]
Gymnema (Gymnema sylvestre) This is a common herb used in traditional Ayurvedic medicine and has been called the herbal form of Metformin.3 It is an anti-diabetic that is characterized by insulin modulating activity which means it regulates insulin levels while controlling sugar or carbohydrate cravings. Gymnema actually numbs the sweet taste areas of the taste buds which helps suppress appetite. Some research has indicated that this herb might stimulate production of cells in the pancreas which in turn increases the levels of insulin in the body.
Chia buto ay itinuturing na isang superfood dahil ito ay isang rich source ng pandiyeta hibla, malusog taba, protina, at mineral. Omega - 3 mataba acids sa anyo ng alpha-linolenic acid (ala) ay naroroon sa chia buto. Sakit sa puso, mataas na kolesterol, at alta presyon ay maaaring lahat ay dinala sa ilalim ng control sa pamamagitan ng ito malusog na anyo ng taba. Chia buto din maglaman ng antioxidants sa anyo ng phenolic compounds (17). Idagdag sila sa iyong ilas na manliligaw, muffins o lamang ng ilang mga yogurt at mayroon ang mga ito araw-araw.
A lot of people only know things about post-junkie Luna and think that it was the drugs that turned her into a bad person. Can't really blame them; the vast majority of pre-Luna discussion/posts consist of pictures of her and her friends, her upbringing, and her short-lived college career. How are they going to know that she was a cunt prior to getting hooked?
There are also experts who suggest taking more of a lifestyle treatment approach rather than medication, which some call a “Band-Aid” to symptoms. One such expert is Amy Medling, a certified health coach who is founder of PCOS Diva and author of Healing PCOS: A 21-Day Plan for Reclaiming Your Health and Life with Polycystic Ovary Syndrome. She stresses that some women don’t feel well on some of these drugs (she was one of them), so looking at other ways to manage PCOS will get them to a more balanced place. “I hear from many women who are frustrated and hopeless and feel underserved by the mainstream way of managing PCOS,” says Medling.
Why treat IR in PCOS women? For many years only PCOS women with DM were treated. As the link between IGT and CAD became more apparent, many PCOS women with IGT were treated. We now understand that IR is often the first step in a progression to DM and CAD. Those who now advocate treatment for IR do so for the following reasons: reduction of insulin and androgen levels, prevention of IGT and DM, potential for improved ovulation, symptomatic improvement, prevention of MS[63]. Ultimately, secondary prevention in young women with identifiable and treatment precursor conditions is far more desirable and easier than treatment of these same women later in life with serious disease.

El ginecólogo o el endocrinólogo te preguntará sobre cualquier síntoma o preocupación que puedas tener, tu salud en el pasado, la de tu familia, los medicamentos que tomas, las alergias que tienes y otras cuestiones. También te hará muchas preguntas específicas sobre tu período menstrual y sus irregularidades. Esto le permitirá tener tus antecedentes médicos.
Irregular uterine bleeding from PCOS is usually due to lack of ovulation. Under this circumstance, the fragile lining of the uterus (endometrium) becomes thickened from excess estrogen and is not corrected by the monthly production of progesterone from the ovary that normally follows ovulation. Consequently, oral contraceptives (which contain progesterone-like substances), progesterone alone, or possibly a progestin-releasing intrauterine device, can be used to reverse the actions of estrogen on the uterine lining. Rarely, abnormal uterine bleeding after childbearing that does not respond to medical therapy may require surgical therapy.
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Contrary to the implication of “polycystic,” some women with the condition don’t have any cysts. A diagnosis requires only two of the following three criteria to be met: elevated levels of male sex hormones (which can cause excess hair growth, acne, and baldness), irregular or absent periods, and/or at least 12 follicular cysts on one or both ovaries.
hi dok. kagagaling ko lang po sa OB ko knina at first time ko po mag pa check up at nalaman ko nga po na my PCOS po ako, my posibilidad po pala na mbuntis po ako, june po darating asawa ko, my posibilidad na po kaya na makabuo po kame bago po sya bumalik sa work nia ? niresetahan po ako ng metformin at tska po ung kulay yellow na parang fish oil.. my mas better pa po ba na gamot bukod po dun ?
Other insulin sensitizing agents have been advocated and studied for the treatment of IR in PCOS, principally thiazolinediones. Thiazolinediones stimulate gene transcription that alters lipid and glucose metabolism, decreases lipolysis and decreases fat deposition[90]. Thiazolinediones decrease fatty acid release, suppress gluconeogenesis and reduce tumor necrosis factor α disruption of insulin activity[64]. Pioglitazone and rosiglitazone have decreased IR (measured by clamp studies) in PCOS women[90-93]. Glitazones have also decreased IR by OGTT AUC-Insulin in PCOS women[91,93,94]. In patients with DM, thiazolinediones reduce central adiposity[95], a trait commonly shared with PCOS women. Pioglitazone by way of IR and adiponectin levels also has improved menstrual regularity in PCOS women[96,97]. Adverse outcomes have been seen in pregnant animals with limited to no human data. Therefore, as a class, thiazolinediones are not considered first line therapy for PCOS women seeking pregnancy. Rosiglitazone has even been found to decrease pro-inflammatory markers in human granulosa cells cultured following in vitro fertilization oocyte retrieval, thus showing additional target tissue for therapy[98]. However, these effects have not been adequately studied and have no current practical application.

Polycystic ovary syndrome (PCOS), also known as polycystic ovarian syndrome, is a common health problem caused by an imbalance of reproductive hormones. The hormonal imbalance creates problems in the ovaries. The ovaries make the egg that is released each month as part of a healthy menstrual cycle. With PCOS, the egg may not develop as it should or it may not be released during ovulation as it should be.
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