No. Seroquel doesn't have a 'noticeable effect on your perception of reality'. I don't know where you get that shit but seriously, it just knock you out cold. There's no high like in benzos, there's no euphoria like in ambien. You take it and either you are sedated if the dosage is mild or you pass out if it's too much. It's supposed to calm you down and turn you in a zombie. But again, it's not the sedation you get on benzos. It's not enjoyable, you feel shitty and slow. Nobody would take that to be high, you don't feel relaxed, ffs.
“When any condition crosses disciplines and doesn’t have a full investment in [one of them], it often falls through the cracks. There are elements of reproduction in PCOS, but most reproductive endocrinologists mostly do in-vitro fertilization and are not necessarily interested in metabolism. Medical endocrinologists, who are mostly interested in metabolism, aren’t usually interested in reproduction and ovarian function,” Dumesic said.
Ano nga ba ang PCOS? Ito ay isang hormonal disorder kung saan nagkakaroon ang babae ng mga maliliit na cyst sa kanyang obaryo. Naglalaman ang mga cyst na ito ng mga immature egg cells na hindi kayang mag-trigger ng proseso ng obulasyon. Ibig sabihin, bababa ang lebel ng female hormones tulad ng estrogen at progesterone, at tataas ang lebel ng male hormones katulad ng androgen. Ang imbalance na ito ay magdadala ng iba’t ibang sintomas at epekto sa katawan.
With our 5-Element System, we show you how to use Food as Medicine to balance your insulin levels and hormones. Our 5% solution…making small changes over time using our diet plans, recipes, and 24/7 support…will help you to successfully change your eating habits, choosing foods to support your healing and eliminate those persistent sugar and simple-carb cravings.
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Key terms for the first search included: title or abstract CONTAINS ‘herbal medicine’ OR ‘herbal extract*’ OR ‘phytotherapy’ OR ‘botanical’ AND title or abstract CONTAINS ‘androgen*’ OR ‘oestrogen*’OR ‘follicle stimulating hormone’ OR ‘luteinising hormone’ OR ‘prolactin’ OR ‘insulin’ OR ‘glucose’ OR ‘polycystic ‘ovar*’. Search terms for the second search included the following key words in the title or abstract, CONTAINS; ‘menstrual irregularity’ OR ‘oligomenorrhoea’ OR ‘amenorrhoea’ OR ‘hyperandrogenism’ OR ‘hirsutism’ OR ‘acne’, OR ‘polycystic ovary syndrome’ OR ‘PCOS’ OR ‘polycystic ovar*’ OR ‘oligo-ovulation’ OR ‘anovulation’ OR ‘fertility’ OR ‘infertility’ OR ‘pregnancy’ AND ten herbal medicines identified from the laboratory search; ‘Cimicifuga racemosa’ OR ‘Cinnamomum cassia’ OR ‘Curcuma longa’ OR ‘Glycyrrhiza ‘ OR Matricaria chamomilla OR ‘Mentha piperita’ OR ‘Paeonia lactiflora’ OR ‘Silybum marianum’ OR ‘Tribulus terrestris’ OR ‘Vitex agnus-castus’. Truncation was used to capture plural key words and synonyms, and acronyms were used for some hormones (FSH and LH).

In vitro fertilization represents the third-line treatment for infertility in women with PCOS 9. However, if the initial assessment demonstrates a bilateral tubal occlusion and/or concentration of recovered motile sperm less than or equal to 5 million, this treatment becomes the first option along with lifestyle changes. The risk of OHSS is the main complication of the highly complexity treatment in women with PCOS. Thus, to minimize this side effect, ovarian stimulation should be initiated with low doses of gonadotropins (100 to 150 IU of FSHr) and the pituitary should be suppressed with a gonadotropin-releasing hormone (GnRH) antagonist because this method is associated with a reduced risk of OHSS compared with an agonist (29 randomized control trials (RCTs); OR 0.43; 95% CI: 0.33 to 0.57) 32. If the patient presents with clinical and ultrasound signs of OHSS, final oocyte maturation should be performed with a GnRH agonist and embryos should be frozen and transferred in a subsequent cycle 33,34. Infertile women with PCOS may present with better general oocyte and embryo quality rates; however, the clinical pregnancy and live birth rates are similar to those observed in normo-ovulatory women without PCOS 35.
If Chief goes to jail or gets probation, then she may have to. Or otherwise will eventually have to at some point. When addicts' junkie luck runs out and they begin to lose their basic comforts/necessities, they start to do things that they told themselves they'd never do. Nobody started out on heroin telling themselves that they'd do anything for the drug.
One strategy that may help some of you: Have a big breakfast. When a group of normal weight women with PCOS got a whopping half of their daily calories first thing in the morning, insulin levels dropped 8% and testosterone levels fell 50% in three months.13 And that’s not all. These women ovulated more frequently and had improved insulin sensitivity in comparison to another group of women in the study who more of their calories at dinner.13
Women with polycystic ovary syndrome have menstrual disorders caused by the absence of ovulation. About 20% of women will not ovulate on clomiphene citrate, the primary treatment option. These women can be treated with a surgical procedure like laparoscopic electrocautery of the ovaries or by ovulation induction with gonadotrophins or gonadotrophin releasing hormone (GnRH). In normal menstrual cycles, GnRH is released in a regular pulsatile interval. A portable pump can be used to mimic this pulse to help these women to ovulate and hopefully to get pregnant. The review of trials did not find enough evidence to show the effectiveness of pulsatile GnRH in women with polycystic ovary syndrome.

besides that, I'm not really sure why it takes so long. American courts in general are notoriously slow. every tiny thing gets adjourned, it's weird. I got into a methadone program while still going to court. I wasn't ordered to or anything. I told my lawyer. he told the judge. the judge said "good job, keep it up, see you next month! adjourned!" and moved on to the next person
Polycystic ovarian syndrome is classified as a disorder which encompasses a group of symptoms that collectively indicate a distinct health issue. This means that the symptoms associated with PCOS will vary from woman to woman. Your PCOS experience is probably very different from another woman with this condition but that does not mean you are alone! PCOS is a condition which can affect between 5 – 10% of all women and is the most common cause of infertility.8 You may be wondering how you ended up in this group of women but unfortunately the precise reason polycystic ovarian syndrome develops isn’t completely clear. 8 Having said that, many experts believe insulin as well as hormone imbalances have a strong influence on PCOS and the severity of its symptoms.
Habang remedyo sa bahay ay maaaring maging isang mahusay na pagpipilian para sa paggamot ng PCOS, naghahanap ng medikal na tulong ay din napakahalaga sa karamihan ng mga oras. Makipag-usap sa iyong doktor tungkol sa iyong mga plano upang bigyan ng bahay remedyong subukan mo upang ang mga pinakamahusay na posibleng mga kumbinasyon ng paggamot ay maaaring devised para sa iyo. Gayundin, PCOS ay madalas na nauugnay sa isang hindi malusog lifestyle at diyeta. Para sa ito, kami ay compiled ng isang listahan ng mga maingat mga panukala na maaari mong sundin upang labanan ang kundisyong ito.
The prevalence of depression in women with polycystic ovary syndrome (PCOS) is high; a study has shown it to be four times that of women without PCOS. Therefore, systematic evaluation of the effectiveness and safety of antidepressants for women with PCOS is important. We found no evidence to support the use or non‐use of antidepressants in women with PCOS, with or without depression. Well‐designed and well‐conducted randomised controlled trials with double blinding should be conducted.

Niveles elevados de insulina. La insulina es una hormona que contribuye en el procesamiento de los alimentos hasta convertirlos en energía. La resistencia a la insulina se da cuando las células corporales no responden normalmente a la insulina. Como consecuencia, los niveles de insulina en sangre están más elevados de lo normal. Muchas mujeres con SOP tienen resistencia a la insulina, en especial aquellas con sobrepeso y obesidad, que tienen hábitos alimenticios poco saludables, no realizan suficiente actividad física o tienen antecedentes familiares de diabetes (por lo general, diabetes tipo 2). Con el paso del tiempo, la resistencia a la insulina puede desencadenar diabetes tipo 2.
However, in women with PCOS receiving low doses of gonadotropins for timed intercourse, metformin administration can double the clinical pregnancy rate (OR 2.25; 95% CI: 1.50 to 3.38; p<0.001; 7 trials) and the live birth rate (OR 1.94; 95% CI: 1.10 to 3.44; p=0.020; 2 trials). Moreover, this practice can reduce the cancellation rate due to ovarian hyperresponsiveness by approximately 60% (OR 0.41; 95% CI: 0.24 to 0.72; p=0.002; 7 trials), the number of days of stimulation (mean difference (MD)=-3.28; 95% CI: -6.23 to 0.32; p=0.030; 6 trials) and the dose of gonadotropins (MD=-306.62; 95% CI: -500.02 to -113.22; p=0.002; 7 trials) in low-complexity cycles. However, the use of metformin is not related to a reduction in the multiple pregnancy rate (OR 0.32; 95% CI: 0.08 to 1.23; p=0.100; 3 trials), a change in the miscarriage rate (OR 0.47; 95% CI: 0.14 to 1.54; p=0.210; 5 trials) or OHSS (OR 0.56; 95% CI: 0.26 to 1.21; p=0.140; 5 trials). Notably, no conclusive data are available on the appropriate dose and time (pre-treatment or during gonadotropin treatment) for the use of metformin during timed intercourse with gonadotropins 37.
Many doctors prescribe the drug metformin to help regulate the amount of glucose in the blood. The medication is traditionally used to treat Type 2 diabetes, as it makes the body more sensitive to insulin, and decreases the amount of glucose the liver releases. A meta-analysis published online in June in the journal Human Reproductive Update demonstrated that when metformin is combined with lifestyle modifications such as diet and exercise, it has been shown to help women with PCOS lose more body fat, achieve lower blood sugar, and improve menstruation better than lifestyle modification alone.
One time when I was in a&e this junkie was having withdrawals and literally shitting and puking everywhere. The stench was unreal to the point they had to move other patients out of the area, as it was making people sick. The nurses were fucking pissed off and disgusted, of course they couldn't say anything in front of him, but they were bitching about it when they came into my room. The world is not there to entertain and 'ooh' and 'aww' over your projectile shit, Tuna. Stop being a disgusting adult baby.
Christina Holaday - I am so excited about the changes I have already had. I started taking the Insulite supplements as soon as they arrived. The first couple days I didn't notice much but the next day I had an abundance of energy. I wanted to do everything and had energy to do it. I love how I feel right now and will continue to focus on making the necessary diet and movement changes slowly. This Insulite System has given me my hope back. I feel happy and motivated which I haven't felt in months. I hope this can encourage others because I was at the end of my rope. Thanks for listening”
A prospective, observational clinical trial examined the endocrine effects of Tribulus terrestris 750 mg per day, over five days in eight healthy women (aged 28–45). A significant increase in mean serum FSH concentration from 11 mIU/ml before treatment to 17.75 mIU/ml following treatment (P < 0.001) was demonstrated. Pre-treatment FSH levels returned following cessation of treatment (Table 1). Another clinical study evaluated the equivalence of Tribulus terrestris (Tribestan®) and pharmaceuticals for ovulation induction in women with oligo/anovular infertility (n = 148), [60]. During the three month follow up, ovulation rates were highest with epimestrol (74%), followed by Tribulus terrestris (60%), clomiphene (47%) and cyclofenil (24%). However, the evidence for Tribulus terrestris should be interpreted with caution due to risks for bias in clinical studies. One study was uncontrolled with a small number of healthy participants [56], the second study did not report baseline characteristics, methods for allocation to treatment groups and data were not statistically analysed [60] (Table 1).
... Evidence suggesting that the syndrome may originate in the hypo- thalamus, due to a primary neuroendocrine defect in gonadotropin-releasing hormone (GnRH) secretion that leads to increased frequency and amplitude in the pulses of the secretion of luteinizing hormone (LH) [11]. Recent studies suggests that ovarian innervation also plays a role in the physiopathology of the syndrome, since it has been observed that, in both, rodent with the induced pathology and women with the syndrome, there is an increase in sympathetic ovarian nervous activity [12][13][14][15]. ...
For women who desire pregnancy, a medication called clomiphene (Clomid) can be used to induce ovulation (cause egg production). In addition, weight loss can normalize menstrual cycles and often increases the possibility of pregnancy in women with PCOS. Other, more aggressive, treatments for infertility (including injection of gonadotropin hormones and assisted reproductive technologies) may also be required in women who desire pregnancy and do not become pregnant on Clomid therapy.
Fertility Treatments: Once other possible reasons for infertility in you and your partner have been ruled out, your gynecologist or fertility specialist may recommend the drug clomiphene (Clomid) to induce ovulation. Six months of treatment has been known to achieve successful pregnancies for about 20-40% of women with PCOS,19 according to ACOG. If clomiphene is tried and isn’t effective, you may be given gonadotrophins to try and jumpstart your ovaries.
Well, I see it as nitpicking because it's not funny, boring and over talked about. We all know she has saggy tits, it doesn't need to be pointed out every time a new pic is posted. and I've always thought and said she hated herself before the tit thing, it's not that people are suddenly jumping to this conclusion now, it just started a discussion about it.
Pioglitazone (Actos®) and Rosiglitazone (Avandia®) are insulin-sensitizing agents that improve glucose tolerance and insulin resistance. These drugs are approved by the Food and Drug Administration (FDA) for the treatment of diabetes. Although they are not approved for treatment of PCOS, they have been shown to be effective for this purpose in many studies.
Regardless of what reasons women have for seeking diagnosis and treatment of PCOS, it is imperative for practitioners to assess a woman’s risk for CAD. Assessment should probably be made in all PCOS patients regardless of BMI. Especially in young women or adolescents, IR may be the first identifiable risk factor. Practitioners must recognize that no universal test for IR exists and must use good clinical judgment to assess metabolic status in women. Stimulated testing with OGTT may be more sensitive than fasting measurements. Women who demonstrate IR should be counseled on lifestyle modifications. Physicians should discuss with their patients a target BMI that is realistically obtainable. It is often advisable for patients to seek nutritional assessment and counseling to help with this goal. In many individuals, consideration should be given to pharmacological treatment. Although the most commonly used medication is metformin, other medications may be appropriate first line therapy, especially in women not actively seeking pregnancy.
Hi dok bru.. Nabasa ko po mga message nyo.may gusto lng po ako e ask. I have pcos po and were trying na mgka baby kmi ng asawa ko. Folic acid at cristane sa asawa ko bingay ng obgyn nmin but after a year wla pa dn po. Sbi nila try ko daw mag antibirth pills at stop ko daw after a month daw para mbuntis daw po.Anu po maging epekto nun e di pa po ako naka try manganak. Hnd ko pa dn po na try takot po ko.thnx po

It's good to know I'm not alone with having pcos. I found out when I was 18 years old. When I was gr...owing up and in puberty I never had my period. I remember girls around me complaining about there's in high school. But mine never came. I went to a obgyn when I was 16 she gave me meds to get it started, it only worked when I took the med every 3 months. They also did an ultrasound and found multiple cysts on my ovaries, but she did not know what it was. So I never went back to that doctor she was not very bright. But when I was 18 I was reading a magazine about a girl that has pcos and the symptoms and everything, and it sounded like me. So i went to My mom's obgyn and talked to him about what I read and my history of not getting my period on my own, he did an exam, ran some blood tests, and did other ultrasound. Come to find out I have pcos and was put on birth control and metformin. Which I'm still taking and it's been 11 years since I found out I have pcos. See More
There have been many studies on PCOS in the past several years; however, most are fairly small. Also, many studies examine medication effects on surrogate markers (e.g., androgen levels) rather than clinical outcomes (e.g., hirsutism). The study results are often conflicting, and in a recent systematic review, only 33 of 115 possible studies met basic inclusion criteria (e.g., randomized controlled trials), suggesting that many of the data in the literature may have methodologic flaws.1

El síndrome de ovario poliquístico (SOP), también conocido como síndrome ovárico poliquístico, es una afección común causada por un desequilibrio de las hormonas reproductivas. Este desequilibrio hormonal genera problemas en los ovarios. Los ovarios son los encargados de producir los óvulos que se desprenden todos los meses como parte de un ciclo menstrual saludable. Si una mujer tiene SOP, el óvulo puede no desarrollarse o no desprenderse durante la ovulación como debería.
I've never believed that she could get together $1700 on rent ALONE. I don't know much about U.S benefits but in the UK for an under 25 year old unemployment check is just about £60 a week. Even disability allowance wouldnt support the cost of a house like that and their drug habit. Seems impossible that they'd be paying for the house without help from Roger or family members
OGTT with 75-g glucose and hourly glucose and insulin measurements has been compared to clamp techniques. Insulin sensitivity calculated by mathematical transformation of measurements has shown good correlation with glucose disposal using clamp techniques[48]. Although the OGTT is easy to perform, these calculations are more complex and make this particular calculation less desirable for clinical use. However these data show that 1 and 2 h levels are often needed to diagnose IR and stress the potential for false negative results with fasting measurements alone. In patients undergoing clamp and OGTT no correlation was observed between fasting glucose/insulin ratios and IR on the clamp[48].
PCOS contribuye a equilibrar los niveles hormonales, ayudando por ejemplo a la regulación de los ciclos y disminuyendo visiblemente otros síntomas como el crecimiento de vello o el acné. Ten en cuenta que el vello que ya tenías no desaparecerá por sí mismo aunque regules tus niveles hormonales, pero sí que se atenuará el ritmo con el que sale el vello y podrás recurrir a métodos para eliminar el que quede, como por ejemplo la depilación láser.
Key terms for the first search included: title or abstract CONTAINS ‘herbal medicine’ OR ‘herbal extract*’ OR ‘phytotherapy’ OR ‘botanical’ AND title or abstract CONTAINS ‘androgen*’ OR ‘oestrogen*’OR ‘follicle stimulating hormone’ OR ‘luteinising hormone’ OR ‘prolactin’ OR ‘insulin’ OR ‘glucose’ OR ‘polycystic ‘ovar*’. Search terms for the second search included the following key words in the title or abstract, CONTAINS; ‘menstrual irregularity’ OR ‘oligomenorrhoea’ OR ‘amenorrhoea’ OR ‘hyperandrogenism’ OR ‘hirsutism’ OR ‘acne’, OR ‘polycystic ovary syndrome’ OR ‘PCOS’ OR ‘polycystic ovar*’ OR ‘oligo-ovulation’ OR ‘anovulation’ OR ‘fertility’ OR ‘infertility’ OR ‘pregnancy’ AND ten herbal medicines identified from the laboratory search; ‘Cimicifuga racemosa’ OR ‘Cinnamomum cassia’ OR ‘Curcuma longa’ OR ‘Glycyrrhiza ‘ OR Matricaria chamomilla OR ‘Mentha piperita’ OR ‘Paeonia lactiflora’ OR ‘Silybum marianum’ OR ‘Tribulus terrestris’ OR ‘Vitex agnus-castus’. Truncation was used to capture plural key words and synonyms, and acronyms were used for some hormones (FSH and LH).
Removing or slowing the growth of excess hair.  Shaving, bleaching, plucking, waxing, and applying over-the-counter hair-removal creams are effective, albeit temporarily methods to get rid of unwanted excess hair. For more permanent results, you might try laser hair removal or electrolysis but these are expensive, require repeated treatments, and are not guaranteed to be successful.
Clinical investigations found no adverse effects for the six herbal medicines included in this review (Table 2). A comparative study investigating the pharmaceutical Bromocriptine and the herbal medicine Vitex agnus-castus found no side effects associated Vitex agnus-ca stus compared to 12.5% of participants taking Bromocriptine reporting nausea and vomiting [63]. No studies comparing the effectiveness for herbal medicines and the oral contraceptive pill in PCOS, oligo/amenorrhoea and hyperandrogenism were found.
The catch is that it’s not safe in pregnancy, as it can cross the placenta and harm a fetus. For that reason, doctors prescribe spironolactone along with combination estrogen-progesterone birth control pills. If a woman doesn’t want to take these, they have other options, like a progesterone-releasing intrauterine device (IUD). The benefit of using combination birth control pills and spironolactone is that they work even better together, she says.
PCOS stands for polycystic ovary syndrome. The exact cause of PCOS is unknown. What is known is that PCOS has to do with hormone imbalances. With PCOS, your body may have high amounts of two hormones: androgen and insulin. These hormonal issues can cause changes in your body’s ability to release an egg (ovulate) and can lead to irregular periods, ovarian cysts, trouble getting pregnant, and other symptoms.
i wonder if luna's dad knows about how much she complains about him. all he would have to do is google her name to see how much she hates him. if i were her dad and i saw the shit she says about me, i'd kick her to the curb. poor dude is letting her have what she wants, when she wants it, and she STILL talks about him like he's a monster. maybe he's a piece of shit but damn, at least he's trying. what an ungrateful brat
She is mentally ill and on tons of drugs all day long? Focusing on something shallow is doable in that kind of state. Plus she gets asspats for being cyberbullied by a mean forum lol. If she genuinely confronted the fact that she completely and utterly fucked up her life, that everything is her fault and she really just sucks as a person inside and out, she'd probably have a massive breakdown. She just numbs all of these feelings with drugs.
Paeonia lactiflora in combination with Cinnamomum cassia Aqueous extract Unkei-to Paeonia lactiflora and Cinnamomum cassia combination was investigated for steroid hormonal effects on cultured human granulosa cells (obtained from women undergoing IVF). Cells were incubated with different doses for 48 hours [42] One clinical trial investigated the effects of Paeonia lactiflora and Cinnamomum cassia combination (Unkei-to) [57]. This single arm study included amenorrheic women aged 17–29 years (n = 157) with a sub group of women with hyper-functioning oligo/amenorrhoea (n = 42). Ovulation occurred in 61.3% of primary amenorrheic women and in 27.3% of secondary amenorrheic women following two months of treatment [57]. 1. Increased granulosa production of oestradiol [42].

Along with the hormonal imbalance and insulin resistance, Medling says that chronic, low-grade inflammation is the third player in the syndrome. (5) Follow an anti-inflammatory diet, which includes nutrient and fiber-rich produce that are low on the glycemic index (like apples and berries), grass-fed meats, organic poultry, as well as sources of omega-3s (like chia seeds and fatty fish) and avoids inflammatory, heavily processed foods, like french fries, potato chips, cake, and cookies. You’ll also want to keep track of foods that bother you (like if dairy gives you gas) and avoid those to help you feel better, she says. (6)


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Androgens. All females make androgens (also referred to as “male hormones”), but there are often higher levels of androgens in women with PCOS. The excess androgens are produced mostly by the ovaries, but the adrenal glands can also be involved. Excess androgens are responsible for many PCOS symptoms including acne, unwanted hair, thinning hair, and irregular periods.
PCOS is genetic and presents differently in each woman of childbearing age. For some women, symptoms emerge shortly after they begin menstruating. Others may not show signs of the disorder until later in life, or after substantial weight gain, and many don’t receive a diagnosis until they are struggling to get pregnant. A community-based prevalence study published in 2010 found that approximately 70 percent of the 728 women in the cohort had PCOS, but had no pre-existing diagnosis.  
Reproductive dysfunction in PCOS women may also be a manifestation of IR. Menstrual cycle irregularity has been correlated with HOMA-IR[37]. Molecular defects in insulin action may be responsible for reproductive difficulties in PCOS women. Although endometrial tissue appears morphologically similar in PCOS to controls and may have similar insulin receptor prevalence, insulin receptor action at the local endometrial level is impaired and may be reflected in lower pregnancy implantation rates[38]. HOMA-IR has been correlated with follicle count in PCOS during in vitro fertilization[39]. Follicular insulin levels correlate with pregnancy outcome after IVF[40]. These are areas of unresolved understanding with regard to PCOS. Proposed mechanisms for insulin reproductive abnormalities include abnormalities of ovarian steroidogenesis, excessive LH secretion and abnormalities in glucose uptake[41]. PCOS women have been found to have post-receptor insulin abnormalities as well as reduced peripheral insulin receptor binding[42].
The unfortunate truth is that there is no cure for PCOS. But because the disorder can have a profound effect on your health and well-being, treatment is a must. There is one important thing to know about your options: Because the cause of PCOS is still unknown, appropriate therapies are based on a woman’s individual concerns. Is she bothered most about excess hair growth? Does she want to have a baby? Does she need to get her periods back on track?
Dr. Victor Luna completed his medical education at Escuela Autonoma de Ciencias Medicas de Centroamerica in San Jose, Costa Rica. He then participated in an internship at LSU Health Science Center where he later completed his residency in Internal Medicine where he served as the chief resident for his final year. Dr. Luna continued his education by completing a fellowship at University of South Florida.
A long-term study suggested that metformin continued to improve the metabolic profile of women with PCOS over a 36-month treatment course, particularly improving circulating high-density lipoprotein cholesterol (HDL-C), diastolic blood pressure, and body mass index (BMI). [61] However, data are insufficient as yet to recommend metformin to all women with PCOS.
Although metformin is associated with better clinical pregnancy rates (positive beta hCG) (pooled OR 2.31; 95% CI: 1.52 to 3.51; 8 trials; 707 women), there is no evidence of better live birth rates (the main variable used to evaluate the effectiveness of a treatment for infertility) when this drug is used alone (pooled OR 1.80, 95% CI: 0.52 to 6.16; 3 trials; 115 women) or in combination with CC (pooled OR 1.16; 95% CI: 0.85 to 1.56; 7 trials; 907 women) 36. From a reproduction standpoint, there is also no benefit for its use in short (less than four weeks) or long (more than four weeks) periods prior to starting CC treatment in women with PCOS. Therefore, the use of metformin should be restricted to the treatment of glucose intolerance or type 2 diabetes in women with PCOS and should not be used to induce ovulation 9,36.
34. Griesinger G, Schultz L, Bauer T, Broessner A, Frambach T, Kissler S. Ovarian hyperstimulation syndrome prevention by gonadotropin-releasing hormone agonist triggering of final oocyte maturation in a gonadotropin-releasing hormone antagonist protocol in combination with a "freeze-all" strategy: a prospective multicentric study. Fertil Steril. 2011;95(6):2029–33. http://dx.doi.org/10.1016/j.fertnstert.2011.01.163 [PubMed]

One of the biggest challenges in reviewing the evidence for PCOS treatment is that many manifestations of the condition may be components of other disease processes. For example, there may be a study of medications that are useful for hirsutism, but the patient population in the study did not explicitly have PCOS. Thus, recommendations specific for treating symptoms of PCOS may be lacking. When reviewing a study of the treatment of insulin resistance in a general population, it cannot be assumed that the outcomes would mirror those in women with PCOS.
Metformin has been tested in combination with cholesterol lowering medications. Pretreatment of obese PCOS patients with atorvastatin (20 mg per day for 3 mo) followed by 3 mo of metformin (1500 mg per day) resulted in more effective lowering of HOMA-IR than metformin alone[80]. Other similar data show that combined treatment with metformin and atorvastatin compared to metformin alone produced similar but significant improvements in IR. Combination therapy only showed successful reduction of hyperandrogenism and not IR[81].
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Treatments for hirsutism in women with PCOS are similar to those in women without PCOS, such as patients with idiopathic hirsutism. There are many nonpharmacologic treatment options, including electrolysis, waxing, bleaching, plucking, depilatory creams (a form of hair removal that dissolves the hair), thermolysis (use of heat), and laser therapy. Several medications have been studied for the treatment of hirsutism in women with PCOS. First-line agents include spironolactone (Aldactone)22,23,28–30 and metformin,13,16,20,22,31–33 as well as eflornithine (Vaniqa) for facial hirsutism.9

Any lawfags here that can help us out understanding this? From what I roughly gather he's only had Pre-Arraignment so today would be a formal Arraignment deciding whether or not to ask for bail. But his court info says he's already been given ROR so it seems pointless now to come back and decide whether or not to ask for bail or take him to Rikers.

PCOS is the most common endocrinopathy among reproductive-aged women in the United States, affecting approximately 7% of female patients.1 Although its exact etiology is unclear, PCOS is currently thought to emerge from a complex interaction of genetic and environmental traits. Evidence from one twin-family study indicates that there is a strong correlation between familial factors and the presence of PCOS.2


Si una chica tiene sobrepeso u obesidad, el médico le recomendará perder peso. La pérdida de peso puede ir muy bien para atenuar muchos de los problemas de salud relacionados con el síndrome de ovario poliquístico, como la hipertensión y la diabetes. A veces, sólo con perder peso, se consigue restaurar las concentraciones hormonalejavascript:void(0)s normales y, como consecuencia, muchos de los síntomas desaparecen o disminuyen.
Azziz R; Woods KS; Reyna R; Key TJ; Knochenhauer ES; Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004 Jun;89(6):2745-9. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004 Jan;81(1):19-25. 

A 2-hour oral glucose tolerance test can be easily performed to assess the risk of diabetes in a PCOS woman. If necessary, prevention of diabetes may require lifestyle management with weight loss, diet and exercise, and possibly the addition of insulin-sensitizing agents such as metformin, or other medications. Fasting lipid measurements in the blood also can be performed to predict the risk for future cardiovascular disease and may likewise require lifestyle management, along with oral statins and other medications to correct increased triglyceride and low-density lipoprotein (LDL)-cholesterol levels and/or decreased high-density lipoprotein cholesterol (HDL-C) levels.
OGTT with 75-g glucose and hourly glucose and insulin measurements has been compared to clamp techniques. Insulin sensitivity calculated by mathematical transformation of measurements has shown good correlation with glucose disposal using clamp techniques[48]. Although the OGTT is easy to perform, these calculations are more complex and make this particular calculation less desirable for clinical use. However these data show that 1 and 2 h levels are often needed to diagnose IR and stress the potential for false negative results with fasting measurements alone. In patients undergoing clamp and OGTT no correlation was observed between fasting glucose/insulin ratios and IR on the clamp[48].

When a healthy diet and regular exercise aren't enough, medications can make losing weight easier. Different drugs work in different ways. For example, orlistat (Alli, Xenical) stops your body from digesting some of the fat in your food, so it may also improve your cholesterol levels. Lorcaserin (Belviq) makes you feel less hungry. Your doctor will prescribe the medication they think will be the most successful for you.

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The prevalence of insulin resistance in women with PCOS, as measured by impaired glucose tolerance, is substantially higher than expected compared with age-and weight-matched populations of women without PCOS.45 Although insulin resistance alone is a laboratory (not clinical) aberration, it can lead to diabetes, and it may be associated with the metabolic syndrome, thus leading to increased cardiovascular risk.2 As with diabetes, optimal treatment of PCOS requires lifestyle modifications (e.g., diet, exercise) in addition to appropriate medications.
Patients with PCOS who are infertile but desire pregnancy should be referred to a reproductive endocrinologist for further evaluation and management of infertility. Morbidly obese women with PCOS should also be referred for pregnancy risk [2] ; metabolic surgery may be considered in morbidly obese women with PCOS, because many features of this syndrome are reversible with successful weight loss. In vitro fertilization (IVF) is reserved for women with PCOS and unsuccessful gonadotropin therapy or those with other indications for this procedure. [2]
The second-line pharmacological treatment of infertility in anovulatory women with PCOS includes the use of gonadotropins [recombinant follicle-stimulating hormone (FSHr) or human menopausal gonadotropin (HMG)] for timed intercourse or intrauterine insemination (IUI) 9. Due to the higher cost of this therapeutic modality, an evaluation of the tubal patency is recommended prior to initiating the ovarian stimulation with gonadotropins if this procedure was not performed prior to initiating CC treatment. If the fallopian tube is opened and the sperm concentration is suitable for in vivo fertilization, the ovarian stimulation begins with low doses of gonadotropins (37.5 to 75 IU/day or every other day) to achieve monofollicular growth and reduce the risk of complications (OHSS and multiple gestation) 25. US monitoring of the follicular growth (follicular diameter measurement) is mandatory in this case and the endogenous secretion of gonadotropins does not need to be inhibited with gonadotropin-releasing hormone analogues (GnRH-a) during the timed intercourse cycles. The administration of hCG (used to simulate the endogenous peak of luteinizing hormone for final oocyte maturation and ovulation triggering) is unnecessary because it does not increase the probability of conception during ovulation induction cycles for timed intercourse 21. It is important to note that if gonadotropin is chosen as the treatment option, the IUI has a higher likelihood of successful pregnancy compared with timed intercourse in patients with subfertility 26.
Metformin has been the mainstay of treatment for IR and IGT in PCOS women over the past decade. Metformin is a biguanide that acts principally on the liver to inhibit hepatic gluconeogenesis. It also inhibits acetyl-CoA carboxylase activity and suppresses fatty acid production. Metformin acts on skeletal muscle to inhibit lipid production and acts peripherally on adipose tissue to stimulate glucose transport and uptake. Metformin reduces insulin levels and promotes improved insulin receptor activity[64]. Metformin may also have direct and indirect effects on the ovary with respect to insulin action and steroidogenic enzymatic activity. In the endothelium, metformin seems to improve nitric oxide vasodilatory effects. Many other mechanisms of action have been studied in both animal and human models but consistent effects are not always demonstrated with local tissue concentrations that result from therapeutic doses[65].

Bilang kababaihan edad, iba't-ibang mga genetic at hormonal disorder nakakaapekto sa kanilang buhay at kalusugan. Isa tulad ng hormonal kawalan ng timbang na may kaugnayan disorder na nakakaapekto sa mga kababaihan ay Polycystic Ovarian Syndrome (PCOS). Sa ganitong syndrome, dahil sa isang kawalan ng timbang sa mga reproductive hormones, likido-punong cysts punan ang obaryo. Ang mga obaryo makakuha pinalaki at itigil ang gumagana nang normal (1, 2).
PCOS is associated with multiple metabolic defects, including metabolic syndrome. Twice as many women with PCOS have metabolic syndrome as in the general population, and about one-half of women with PCOS are obese.1,9 The presence of PCOS is also associated with a fourfold increase in the risk of type 2 diabetes mellitus.10 There is an increased prevalence of nonalcoholic fatty liver disease,11,12 sleep apnea,13 and dyslipidemia14 in patients with PCOS, even when controlled for body mass index. Rates of cardiovascular disease are higher in patients with PCOS, but increased cardiovascular mortality has not been consistently demonstrated.15,16 Finally, there is evidence to suggest an increased risk of mood disorders among patients with PCOS.17,18

Other tests that may be helpful but are not necessary for diagnosis include measurement of LH and follicle-stimulating hormone (FSH) levels to determine a serum ratio of LH/FSH. A ratio greater than 2 generally indicates PCOS, but there are no exact cutoff values because many different assays are used.26 The FSH level is more helpful in ruling out ovarian failure.26
For assisted reproduction cycles, metformin use prior to or during ovarian stimulation with gonadotropins in IVF/ICSI cycles is also not associated with better clinical pregnancy or live birth rates; however, metformin may reduce the risk of OHSS 38,39 and miscarriage and improve the implantation rate because metformin may act directly on the endometrium 39 and promote better reproductive outcomes (data not confirmed) in women with PCOS 40. However, as previously mentioned, the use of a GnRH antagonist combined with ovarian stimulation with gonadotropins in women with PCOS and the induction of final ovarian maturation with a GnRH agonist with subsequent embryo cryopreservation are more effective strategies to prevent OHSS regardless of metformin use 33. Thus, the routine use of metformin in cycles of ovarian stimulation for IVF in women with PCOS is not recommended except in the presence of a disorder in glucose metabolism 9.
Nigga u wot?? Seriously, read through at least one of her threads before virtue signaling. She is NOT a "sweet woman." She talks shit about everyone once they stop giving her money or ass pats. She claims her dad is the absolute worst and yet brags when he buys her a new grandma bra or when they smoke weed together. She HAS been to rehab, but dropped it once she realized it wasn't a cool place to hang out with druggies.
If these standard treatments don’t work, your doctor may recommend in vitro fertilization (IVF). Your egg is fertilized by your partner’s sperm in a lab, then transferred to your uterus to implant and grow. Your doctor may also recommend a surgical procedure called ovarian “drilling”. Lasers, or a very thin, heated needle, are used to pierce several holes in the surface of your ovary, which improves the chances of successful ovulation for about six to eight months. This is specifically effective for women with PCOS since the outer surface of the ovaries can become extra thick, interfering with the natural process of ovulation.
The Androgen Excess and Polycystic Ovary Syndrome Society recommends lifestyle management as the primary therapy for metabolic complications in overweight and obese women with PCOS. [67] A moderate amount of daily exercise increases levels of IGF-1 binding protein and decreases levels of IGF-1 by 20%. Modest weight loss of 2-5% of total body weight can help restore ovulatory menstrual periods in obese patients with PCOS. A decrease of 500-1000 calories daily, along with 150 minutes of exercise per week, can cause ovulation.
2. Oestrogen receptor binding affinity for Cimicifuga racemosa was studied using pituitary cell cultures from ovariectomised rats. This study followed a clinical study demonstrating significantly lowered LH in post-menopausal women following administration of Cimicifuga racemosa (2 mg for two months) against placebo control (n = 110) [45] 2. Increases luteal progesterone concentration [65, 67, 68]
Maybe anons theory of them using Roger's potential ssi funds for rent isn't to far off? My grandpa used to get like 1200 a month from ssi but it's probably gone up since then and if they get some sort of housing assistance usually they would only have to pay 1/3 of their income. Which would leave plenty to live off of comfortably for the month unless you are using your funds for drugs or useless amazon crap like tuna buys
Diagnosis of PCOS may be difficult because the signs and symptoms can be subtle and varied. The most common manifestations include hirsutism, infertility, insulin resistance, and menstrual irregularities.2 Physicians can diagnose PCOS when other causes of the symptoms or laboratory abnormalities are excluded; when oligo-ovulation or anovulation, usually manifested as oligomenorrhea or amenorrhea, is present; and when there is clinically confirmed hyperandrogenism (e.g., hirsutism, acne). Although the ovaries may be polycystic, this is usually not necessary for diagnosis. There is debate over which criteria should be used (e.g., 1990 National Institutes of Health criteria,3 2003 Rotterdam consensus workshop criteria4). Guidelines suggest screening women with PCOS for other disorders, such as hyperlipidemia, and treating accordingly.5
Paeonia lactiflora in combination with Cinnamomum cassia Aqueous extract Unkei-to Paeonia lactiflora and Cinnamomum cassia combination was investigated for steroid hormonal effects on cultured human granulosa cells (obtained from women undergoing IVF). Cells were incubated with different doses for 48 hours [42] One clinical trial investigated the effects of Paeonia lactiflora and Cinnamomum cassia combination (Unkei-to) [57]. This single arm study included amenorrheic women aged 17–29 years (n = 157) with a sub group of women with hyper-functioning oligo/amenorrhoea (n = 42). Ovulation occurred in 61.3% of primary amenorrheic women and in 27.3% of secondary amenorrheic women following two months of treatment [57]. 1. Increased granulosa production of oestradiol [42].

A su hija la han diagnosticado una afección llamada síndrome del ovario poliquístico ("PCOS", por sus siglas en inglés). El PCOS es un desequilibrio hormonal. Afecta los ovarios. Estos son los órganos que guardan los óvulos de la mujer. El PCOS posiblemente también altere el resto del cuerpo. Si se deja sin tratar, el PCOS puede ocasionar graves problemas de salud. El tratamiento no puede curar el problema, pero sí ayuda a reducir los síntomas y a evitar trastornos de salud.

Glucose tolerance testing (GTT) instead of fasting glucose can increase diagnosis of impaired glucose tolerance and frank diabetes among people with PCOS according to a prospective controlled trial.[70] While fasting glucose levels may remain within normal limits, oral glucose tests revealed that up to 38% of asymptomatic women with PCOS (versus 8.5% in the general population) actually had impaired glucose tolerance, 7.5% of those with frank diabetes according to ADA guidelines.[70]
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