The advantages of CC use are low cost, oral administration, few side effects (flushing, headache, visual disturbances and abdominal discomfort), the induction of monofollicular development in most cases 16 and a low rate of multiple gestations (2 to 13%) 17. The initial dose is 50 mg/day for five days (starting between the second and fifth day of the menstrual cycle) and may be increased to 150 mg/day 17,18; however, doses greater than 100 mg/day usually do not offer additional benefits (may be useful in obese women) 18. The ovulation rate may reach 75 to 80% 19 with a conception rate of 22% per cycle 20 and a cumulative pregnancy rate between 60 and 70% in six cycles 9. There is no evidence that the administration of human chorionic gonadotropin (hCG) in the mid-cycle increases ovulation rates (OR 0.99; 95% CI: 0.36-2.77) or clinical pregnancy (OR 1.02; 95% CI: 0.56-1.89) 21,22. CC treatment should be limited to six ovulatory cycles and US monitoring is not mandatory (it is recommended only in the first ovulatory cycle to adjust the dose based on the ovarian follicular growth and development and for endometrial assessment) 17,18. Additional cycles of ovulation induction with CC (maximum of twelve cycles) may be individually evaluated based on the cost-effectiveness and age of women and after discussion with the couple 9. The incidence of ovarian hyperstimulation syndrome (OHSS; increased capillary permeability with consequent third-space fluid sequestration and hemoconcentration) associated with the use of CC is low, approximately 1 to 6% 17,23.
2. Oestrogen receptor binding affinity for Cimicifuga racemosa was studied using pituitary cell cultures from ovariectomised rats. This study followed a clinical study demonstrating significantly lowered LH in post-menopausal women following administration of Cimicifuga racemosa (2 mg for two months) against placebo control (n = 110)  2. Increases luteal progesterone concentration [65, 67, 68]
To be quite precise (Gastroenterofag here): opioids do slow the metabolism and make you crave sugary crap. Weight gain versus loss depends on whether the dose is high enough to actually be too fucked up most of the day to eat (that's why virtually all thin heroin users who go on methadone or subutex end up ballooning: they're no longer taking astronomical doses of opioids that make them too zonked out to eat, as the cross tolerance allows us to give them about 40% less of the equianalgesic dose). Sage for medfagging.
The use of gonadotropins for timed intercourse is associated with an ovulation rate of approximately 70%, a clinical pregnancy rate of 20% per cycle and a multiple live birth rate of 5.7% 9. Due to the cost of the treatment, the need for regular monitoring of the follicular development via ultrasound and the higher pregnancy rates with IUI, the use of gonadotropin is not routine for timed intercourse. Instead, this medication is used in IUI 26 or high-complexity treatments (IVF or ICSI) 9.
There's no way she can hide it when she's at his house 2 days out of 7. Her Dad also pays for her phone and utilities, she definitely doesn't try to appear okay to her father. She rang him when she OD'd, he's fully aware all her money goes on heroin. He takes her to thrift stores so she'll have something clean to wear in between her weekly laundry runs.
A stroll around the block with your dog (spouse/significant other, neighbor, or exercise buddy), your favorite exercise class at the gym, following a video at home, or peddling on an exercise bike while you watch TV…whatever you choose to get you moving will be good.14 Aim to fit in at least 30 minutes, five times a week – the basic recommendations from the US Centers for Disease Control and Prevention.15
Herbal medicine may present a treatment option for women with oligo/amenorrhoea, hyperandrogenism and PCOS as an adjunct or alternative treatment to pharmaceuticals with a high degree of acceptability by women with PCOS . Preliminary evidence for equivalent treatment effects were found for the two pharmaceuticals and three herbal medicines. These were bromocriptine, in the management of hyperprolactinaemia andVitex agnus-castus and clomiphene for infertility and ovulation induction and Cimicifuga racemosa and Tribulus terrestris. Herbal medicine had positive adjunct effects with the pharmaceuticals Spirinolactone in the management of hyperandrogenism (Glycyrrhiza Spp.), and clomiphene for PCOS related infertility (Cimicifuga racemosa). It is important however to highlight that evidence was provided by a limited number of clinical studies, some with significant risks for bias; particularly Tribulus terrestris, Glycyrrhiza glabra alone and in combination with Paeonia lactiflora and Paeonia lactiflora in combination with Cinnamomum cassia.
Women who do not wish to become pregnant can be effectively treated for hirsutism with oral contraceptives.  Oral contraceptives slow hair growth in 60-100% of women with hyperandrogenemia. Therapy can be started with a preparation that has a low dose of estrogen and a nonandrogenic progestin. Preparations that have norgestrel and levonorgestrel should be avoided because of their androgenic activity. There is also a risk of thrombotic events in obese women who use oral contraceptives; therefore, the proper precautions should be exercised to prevent such events. Oral contraceptives containing cyproterone acetate are also very effective in the treatment of more severe hirsutism  ; however, this combination of agents has not been approved by the FDA for use in the United States.
Ito ay para lamang sa inyong dagdag kaalaman at hindi maituturing na kapalit ng pagkonsulta sa inyong doktor. Huwag uminom ng gamot nang hindi nagpapatingin sa doktor. Mainam na magpatingin sa isang obstetrician-gynecologist (Ob-Gyn). May mga Ob-Gyn na specialists din sa reproductive endocrinology o fertility na maaring makatulong sa mga babaeng may polycystic ovary syndrome (PCOS). Ang doktor ninyo ang magsasabi kung alin ang nararapat na gamot.
Licorice (Glycyrrhiza glabra) Many people take this herbal remedy, especially those being treated with traditional Chinese medicine. Licorice is an adaptogen which can help your body deal with the stress associated with changes, both internal and external. It is particularly effective for lowering testosterone and increasing ovulation when combined with white peony. One of the benefits of licorice for women with PCOS is decreased acne and hair growth.
Women with polycystic ovary syndrome have menstrual disorders caused by the absence of ovulation. About 20% of women will not ovulate on clomiphene citrate, the primary treatment option. These women can be treated with a surgical procedure like laparoscopic electrocautery of the ovaries or by ovulation induction with gonadotrophins or gonadotrophin releasing hormone (GnRH). In normal menstrual cycles, GnRH is released in a regular pulsatile interval. A portable pump can be used to mimic this pulse to help these women to ovulate and hopefully to get pregnant. The review of trials did not find enough evidence to show the effectiveness of pulsatile GnRH in women with polycystic ovary syndrome.
I don't mean to break any hearts, but if something happens to Lurch, the chances of Tuna fixing herself are still near zero. She's addicted to the life, they fight plenty and she has made mention before of hooking customers up, etc. It's very rare for a junkie couple to have one person lifting all the weight. On the off chance he does go away, she'll latch on to someone else and get back into the same role (holding / palming / whatever)
The prevalence of infertility in women with PCOS varies between 70 and 80%. According to the American Society for Reproductive Medicine, the evaluation of infertility in women with PCOS or other causes of subfertility should start after six months of attempting pregnancy without success if the couple has regular sexual intercourse (2 to 3 times/week) without using contraceptive methods 7. To optimize the efficacy of the treatment of infertile women with PCOS, evaluations of tubal patency (hysterosalpingography or laparoscopy with chromotubation) and semen analysis (spermogram) are mandatory before deciding on treatment. However, tubal patency evaluation may not be necessary prior to initiating clomiphene citrate (CC) treatment. Notably, if a patient is resistant to this drug and/or requires the use of gonadotropins and/or presents with other causes of infertility, a tubal patency evaluation becomes mandatory prior to initiating the therapeutic treatment of infertility 8.
This is A LOT of benzodiazepines. I remember the last batch she got too, and it wasn't that long ago. She's using more than I am, and I'm using them legally for a partial spinal cord injury. The FUCK, Luna. Being dependant on heroin isn't enough for you or something? This bothers me more than the heroin, honestly. The withdrawal from benzos can actually kill you, unlike heroin. Not to mention that using multiple CNS depressants together is dangerous af. Narcan won't bring you back from that shit.
Any lawfags here that can help us out understanding this? From what I roughly gather he's only had Pre-Arraignment so today would be a formal Arraignment deciding whether or not to ask for bail. But his court info says he's already been given ROR so it seems pointless now to come back and decide whether or not to ask for bail or take him to Rikers.
Clomiphene is an ovulation induction agent that has been used and studied in patients with and without PCOS.6–8,15,35,36 Studies have found that letrozole (Femara) regulates ovulation and improves pregnancy rates in women with PCOS6,37,38; however, this use is controversial because the drug is FDA pregnancy category D. It is embryotoxic and fetotoxic in animal studies, and there are no studies in pregnant women.
Anecdotally, oral contraceptives are among the most common agents used to treat menstrual irregularities in women with PCOS. However, there are few studies examining their effect on menstrual cycles in women with PCOS. Cyproterone acetate plus ethinyl estradiol has been extensively studied, but it is not available in the United States. Studies suggest that the following agents may improve menstrual irregularities (e.g., oligomenorrhea): spironolactone (in an open-label study),22 acarbose,24 rosigli-tazone,32 and metformin.10,11,32,47,51 Metformin is probably the best choice because it may improve insulin resistance in addition to improving menstrual irregularities.
“Often times the cosmetic issues are huge, depending on the severity. When you summarize the typical PCOS patient as someone who is fat, has acne, and male-pattern baldness, that is definitely depressing, but that in and of itself is not enough to cause depression,” she said. “It’s the hormonal imbalances that have a real neurobiological affect on the brain and we have evidence that the excess of androgens in women is definitely linked to depression.”
Although aromatase inhibitors have been used in women with PCOS as an alternative method to avoid the anti-estrogenic effect of CC on the endometrium, these compounds are not typically used in clinical practice to treat infertility in these patients. Their mechanism of action is based on reducing the peripheral conversion of androgens to estrogens in ovarian granulosa cells by blocking aromatase. Consequently, a decrease in estrogen serum levels and in its negative feedback in the hypothalamus and pituitary gland is noted, resulting in increased endogenous gonadotropin release 41.
Depilar el vello con cera o con pinzas son otras formas de controlar los efectos de su crecimiento (sea en casa o en un salón de belleza). También puedes ir a un dermatólogo (un médico especializado en problemas de la piel) o a un especialista cualificado en tratamientos de depilación por electrolisis o láser quirúrgico. Estos procedimientos permiten eliminar el vello no deseado durante mucho más tiempo, pero también son mucho más caros.
she's mentioned before that "healthy foods" are "rich people foods" which is just total bullshit to anyone who's gone grocery shopping. she used to post cvs hauls of frozen pizzas and candy she'd get for herself and lurch and it would be one nights worth of food. cvs is overpriced as fuck but even at a normal store, buying exclusively prepackaged junk food is expensive as fuuuccck. buy some rice and beans.
For acne or excess hair growth, a water pill (diuretic) called spironolactone (Aldactone) may be prescribed to help reverse these problems. The use of spironolactone requires occasional monitoring of blood tests because of its potential effect on the blood potassium levels and kidney function. Eflornithine (Vaniqa) is a prescription cream that can be used to slow facial hair growth in women.Electrolysis and over-the-counter depilatory creams are other options for controlling excess hair growth.
Human speak: Polycystic ovarian syndrome (PCOS) is one of the most common female reproductive disorders; affecting approximately 10% or more of women worldwide. PCOS is a big deal because it can lead to infertility and other health problems. The common symptoms associated with PCOS are irregular or no periods and anovulation (meaning you don’t ovulate, or ovulate rarely), increases in androgen hormones (like testosterone) and luteinizing hormone (which usually kicks off ovulation, but is persistently high in women with PCOS), and in some cases, insulin resistance and obesity. There is currently no “cure” for PCOS, just management of symptoms.
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
Randomisation for 206 women 12 were excluded due to failure to respond (treatment group n = 7, control n = 5). 2. Endometrial thickness monitored by ultrasound. Endometrial thickness in the clomiphene alone group was 8.5 mm (±1.9) compared to 12.9 (±2.3) in the clomiphene plus Cimicifuga racemosa group (p < 0.001). The miscarriage rate per pregnancy for the clomiphene alone group was 5 out of 33 (15.2%) and 6 out of 71 (8.5%) in the clomiphene plus Cimicifuga racemosa group.
Patients with PCOS who are infertile but desire pregnancy should be referred to a reproductive endocrinologist for further evaluation and management of infertility. Morbidly obese women with PCOS should also be referred for pregnancy risk  ; metabolic surgery may be considered in morbidly obese women with PCOS, because many features of this syndrome are reversible with successful weight loss. In vitro fertilization (IVF) is reserved for women with PCOS and unsuccessful gonadotropin therapy or those with other indications for this procedure. 
For some, lifestyle changes may be all you need to control the symptoms of your PCOS. But for many other women, medications may be necessary to help control harder to manage symptoms, such as fertility, and major risk factors that arise with polycystic ovary syndrome, specifically insulin resistance that leads to diabetes and high blood cholesterol that may end up developing into heart disease.
There are also experts who suggest taking more of a lifestyle treatment approach rather than medication, which some call a “Band-Aid” to symptoms. One such expert is Amy Medling, a certified health coach who is founder of PCOS Diva and author of Healing PCOS: A 21-Day Plan for Reclaiming Your Health and Life with Polycystic Ovary Syndrome. She stresses that some women don’t feel well on some of these drugs (she was one of them), so looking at other ways to manage PCOS will get them to a more balanced place. “I hear from many women who are frustrated and hopeless and feel underserved by the mainstream way of managing PCOS,” says Medling.
Polycystic ovarian syndrome (PCOS) is a highly prevalent hormonal and metabolic disorder among reproductive aged women worldwide. Women with PCOS have widely varying phenotypes and seek medical care for differing reasons. In addition to concern for menstrual cycle function, ovulation, hirsutism and acne, many PCOS women have abnormal glucose metabolism. While diabetes mellitus and impaired glucose tolerance are easily diagnosed, the diagnosis of and concern for insulin resistance as a precursor disorder is underappreciated. Insulin resistance may be the first important marker of metabolic disease in PCOS women at risk for metabolic syndrome and coronary artery disease.
Polycystic ovary syndrome (PCOS) is a condition in which the ovaries produce an abnormal amount of androgens, male sex hormones that are usually present in women in small amounts. The name polycystic ovary syndrome describes the numerous small cysts (fluid-filled sacs) that form in the ovaries. However, some women with this disorder do not have cysts, while some women without the disorder do develop cysts.
Un síntoma clave del síndrome de ovario poliquístico es tener periodos menstruales irregulares o faltas de la menstruación, porque las consecuencias de esta afección sobre los ovarios pueden hacer que se deje de ovular. De todos modos, puesto que una chica puede tardar hasta dos años en presentar períodos menstruales regulares desde su primera menstruación, puede costar mucho reconocer este síntoma en las adolescentes. El desequilibrio hormonal propio de este síndrome puede desencadenar cambios en todo el cuerpo, no solo en los ovarios.
there is no "trial" lmao. you would have flown out for nothing. it's a two minute thing, TOPS. he probably got appointed a public defender today. or maybe not even appointed one, just applied to be appointed one. the first or second time they just ask you to bring in paperwork proving you're poor and need a public defender. when you do get one, the lawyer just keeps adjourning it, like six or more times usually. then you're asked to get into a program or a detox or whatever. at the end he might get probation. each court appearance is less than 5 minutes long.
Pwedeng magrekomenda ang doktor ng mga lifestyle changes bilang PCOS treatment. Kasama dito ang pag-ehersisyo, para sa kahit maliit na pagbawas sa timbang. Ang kawalan ng kahit limang porsyento ng ating timbang ay makakatulong na sa pagbuti ng ating kondisyon. Bilang ehersisyo, tingnan ang pagtakbo, pagbisikleta, paglangoy, o ang mga simpleng routine na kinabibilangan ng mga push-up, crunches, stretching exercises, at iba pa.
PCOS is associated with multiple metabolic defects, including metabolic syndrome. Twice as many women with PCOS have metabolic syndrome as in the general population, and about one-half of women with PCOS are obese.1,9 The presence of PCOS is also associated with a fourfold increase in the risk of type 2 diabetes mellitus.10 There is an increased prevalence of nonalcoholic fatty liver disease,11,12 sleep apnea,13 and dyslipidemia14 in patients with PCOS, even when controlled for body mass index. Rates of cardiovascular disease are higher in patients with PCOS, but increased cardiovascular mortality has not been consistently demonstrated.15,16 Finally, there is evidence to suggest an increased risk of mood disorders among patients with PCOS.17,18
Tulad ng chia buto, kalabasa buto din maglaman ng malusog na wakas - 3 mataba acids na makakatulong sa iyo na pamahalaan ang mataas na kolesterol at mataas na antas ng insulin nakikita sa PCOS (22). Sila rin ay naglalaman ng beta-sitosterol na maaaring alisin ang labis androgens at ituring ang hirsutism, acne at makakuha ng timbang sintomas ng PCOS (23).
One strategy that may help some of you: Have a big breakfast. When a group of normal weight women with PCOS got a whopping half of their daily calories first thing in the morning, insulin levels dropped 8% and testosterone levels fell 50% in three months.13 And that’s not all. These women ovulated more frequently and had improved insulin sensitivity in comparison to another group of women in the study who more of their calories at dinner.13
Insulin-sensitizing agents, including metformin,11,32 rosiglitazone,19,20,32 and pioglitazone (Actos),17 have been effective in improving fertility and ovulation in women with PCOS. There are contradictions in the literature regarding whether metformin, clomiphene, or a combination of the two agents is superior for improving pregnancy rates in women with PCOS. A 2003 Cochrane review suggested that metformin should be a first-line treatment for infertility in women with PCOS.39 A more recent study confirmed that six months of metformin therapy was more effective than six months of clomiphene therapy for improving fertility in anovulatory, nonobese women with PCOS.8 However, a large randomized trial of more than 600 women found that clomiphene is superior to metformin in achieving live birth in infertile women with PCOS, with no statistical benefit to the addition of metformin to clomiphene.40 Another study also showed no benefit from adding metformin to clomiphene.35 However, two meta-analyses suggested that the combination is better than clomiphene alone.41,42 A more recent study found that, although ovulation rates were better with metformin than with clomiphene, pregnancy rates were similar.43 Finally, two systematic reviews found conflicting results; one suggests metformin does not affect ovulation or pregnancy rates,1 and the other suggests it does.44
Traditionally, women with polycystic ovary syndrome (PCOS) have been treated with therapies aimed at relieving specific PCOS symptoms or health risks. Newer treatments being investigated at the University of Chicago Medicine and elsewhere also aim to address what may be a root cause of PCOS: insulin resistance. Many of these new therapies are designed to lower insulin levels, thus reducing production of testosterone.
The ultimate goal is to prevent metabolic disease. Metformin (1500 mg per day) compared to placebo in a prospective 12 wk randomized control trial decreased arterial stiffness (by peripheral pressure waveforms in the brachial artery) and endothelial function (measured by augmentation index). Metformin did not reduce HOMA-IR. The study population was obese but young (mean age 30 years), demonstrating the ability to reduce CAD risk even in very young women. Metformin has reduced both carotid intimal media thickness and endothelin levels in obese PCOS women. In many studies metformin has reduced both total cholesterol and LDL cholesterol levels[84-86], triglyceride levels and increased HDL levels[87,88]. Animal studies have shown that acarbose given to insulin resistant rats decreased carotid intimal hyperplasia and blood flow velocities. Taken as a whole, the ability of metformin (and likely other insulin sensitizing agents) to elicit an overall reduction in the risk for CAD may be easier than the ability to produce consistent measureable improvements.
15. Wolff MS, Teitelbaum SL, Pinney SM, Windham G, Liao L, Biro F, Kushi LH, Erdmann C, Hiatt RA, Rybak ME, Calafat AM. Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls. Environ Health Perspect. 2010;118(7):1039–1046. doi: 10.1289/ehp.0901690. [PMC free article] [PubMed] [CrossRef]
2. amenorrhoea n = 30. Oligomenorrhoea group: Treatment n = 17. Placebo n = 20. Amenorrhoea group. Treatment n = 16. Placebo n = 14. For oligomenorrhoea: Shortened menstrual cycle of at least 4 days. Earlier ovulation of at least 3 days. For anovulatory oligomenorrhoea: Mid luteal progesterone increase (>50% 5–10 days before menstruation. Secondary clinical outcomes, pregnancy rates and take home baby rates. At 6 months following conclusion of treatment, the take home baby rate with treatment was 18.7% compared to 6.4% in placebo group. Not statistically significant.
While PCOS is not curable, symptoms are treatable with medications and changes in diet and exercise. Hormonal imbalances can be treated with birth control pills, androgen blocking medications, or medications that help the body use insulin better. Medications that help the body respond better to insulin may also be helpful. For women whose infertility problems are not resolved with lifestyle changes alone, medications that improve ovulation (fertility drugs) may be helpful.
Losing weight. Healthy eating habits and regular physical activity can help relieve PCOS-related symptoms. Losing weight may help to lower your blood glucose levels, improve the way your body uses insulin, and help your hormones reach normal levels. Even a 10% loss in body weight (for example, a 150-pound woman losing 15 pounds) can help make your menstrual cycle more regular and improve your chances of getting pregnant.3 Learn more about healthy weight.