“When we compared participants with women in the general population, we found significantly higher scores on all of the symptoms evaluated and on corresponding psychological distress measures, particularly for anxiety, depression, somatization (the conversion of psychological distress to physical symptoms), and interpersonal sensitivity,” says lead author Judy McCook, PhD, RN, professor of nursing at East Tennessee State University.
Polycystic ovary syndrome and fertility: What you need to know PCOS is a disorder in which small fluid-filled cysts form in the ovaries. This leads to an imbalance in female sex hormones, with symptoms such as male-pattern hair growth and irregular periods. It can also affect fertility. Tips and treatment for fertility problems include diet, stress reduction, and medical help. Read now
It is thought that insulin resistance may be a key factor in PCOS. Insulin helps transport glucose into the body's cells. where it is needed for energy production. When there is resistance to insulin's effect, the body tries to compensate by making even more insulin and releasing it in the blood (hyperinsulinemia). Some believe that too much insulin may cause the ovaries to increase androgen production, which in turn causes the symptoms associated with PCOS.
For acne or excess hair growth, a water pill (diuretic) called spironolactone (Aldactone) may be prescribed to help reverse these problems. The use of spironolactone requires occasional monitoring of blood tests because of its potential effect on the blood potassium levels and kidney function. Eflornithine (Vaniqa) is a prescription cream that can be used to slow facial hair growth in women.Electrolysis and over-the-counter depilatory creams are other options for controlling excess hair growth.
I thought that too at first (i've been following her since she was like 16, unfollowed for a while, then when i refollowed came back to grimy heroin luna). It's because her hair is longer and she's gotten thinner. That's really it. Everything else from her youth looks so much better. The light in her eyes, the freckles, the friendships, the cute babydoll dresses… She just looked happier…. I mean sure she was chunky and her hair was always mangled, but she was happy and that's much more important IMO.
However, in women with PCOS receiving low doses of gonadotropins for timed intercourse, metformin administration can double the clinical pregnancy rate (OR 2.25; 95% CI: 1.50 to 3.38; p<0.001; 7 trials) and the live birth rate (OR 1.94; 95% CI: 1.10 to 3.44; p=0.020; 2 trials). Moreover, this practice can reduce the cancellation rate due to ovarian hyperresponsiveness by approximately 60% (OR 0.41; 95% CI: 0.24 to 0.72; p=0.002; 7 trials), the number of days of stimulation (mean difference (MD)=-3.28; 95% CI: -6.23 to 0.32; p=0.030; 6 trials) and the dose of gonadotropins (MD=-306.62; 95% CI: -500.02 to -113.22; p=0.002; 7 trials) in low-complexity cycles. However, the use of metformin is not related to a reduction in the multiple pregnancy rate (OR 0.32; 95% CI: 0.08 to 1.23; p=0.100; 3 trials), a change in the miscarriage rate (OR 0.47; 95% CI: 0.14 to 1.54; p=0.210; 5 trials) or OHSS (OR 0.56; 95% CI: 0.26 to 1.21; p=0.140; 5 trials). Notably, no conclusive data are available on the appropriate dose and time (pre-treatment or during gonadotropin treatment) for the use of metformin during timed intercourse with gonadotropins 37.
PCOS women with different phenotypes have been found similarly insulin resistant in response to a 3 h 75 g OGTT. Obese (compared to lean) PCOS women tend to have a higher degree of IR. Correlation between hyperandrogenism and IR is significant in many studies but not as significant as the link between insulin abnormalities and obesity. PCOS women demonstrate greater variation in insulin parameters compared to controls, independent of weight. Animal studies of prenatal testosterone exposure show downstream IR in early postnatal life. Some human data shows a high degree of correlation between hyperandrogenism and IR[35,36] and the relationship between hyperandrogenism and IR seem to differ between PCOS and non-PCOS women.
Diet, exercise, and maintaining a healthy body weight may help many women manage the symptoms of PCOS. These lifestyle changes are recommended to help decrease insulin resistance. Weight reduction can also decrease testosterone, insulin, and LH levels. Regular exercise and healthy foods will help lower blood pressure and cholesterol as well as improve sleep apnea problems. Refraining from smoking cigarettes or other tobacco products also may lower androgen levels.
She's talking about withdrawal symptoms, the nausea/puking and massive diarrhea, lmao. That's just part of withdrawal though, and I'm sure she had access to a toilet? Like, what's wrong with actually going through withdrawal? Maybe I'm old school, but I withdrew cold turkey 9 times in the process of getting clean, and that's the easiest part of recovery. Take loperamide for the diarrhea and deal w/ it. Granted, I did genuinely want to get sober, and I doubt Luna does, but still. Choices, consequences. Don't shoot heroin if you can't handle the diarrhea when you're without it. Pfffft, junkies these days.
Metformin. Metformin is often used to treat type 2 diabetes and may help some women with PCOS symptoms. It is not approved by the FDA to treat PCOS symptoms. Metformin improves insulin's ability to lower your blood sugar and can lower both insulin and androgen levels. After a few months of use, metformin may help restart ovulation, but it usually has little effect on acne and extra hair on the face or body. Recent research shows that metformin may have other positive effects, including lowering body mass and improving cholesterol levels.